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UL23 thymidine kinase [ Human herpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703374, discontinued on 12-May-2015
  • This record was discontinued.

Summary

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Gene symbol
UL23
Gene description
thymidine kinase
Locus tag
HHV1gp034
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human herpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1, nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 2,3-Dihydroxy-quinoxaline, a small molecule that promotes ATPase catalytic activity of Herpes Simplex Virus thymidine kinase (HSV-TK), was identified by virtual screening
    Title: 2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase.
  2. The biological evaluation indicated the feasibility of using HHB-5-[1bF]FEP as a PET radiotracer for monitoring HSV1-tk expression in vivo.
    Title: Synthesis and biological evaluation of a new acyclic pyrimidine derivative as a probe for imaging herpes simplex virus type 1 thymidine kinase gene expression.
  3. Nucleotide sequence analysis of UL23 for a population of HSV-1 strain L2.
    Title: [Molecular-genetic analysis of DNA pol and TK of HSV-1 population using NGS technology].
  4. Our results showed that the plasmid vectors carrying the TK and TAT-TK fusion protein gene driven by the survivin promoter were successfully constructed and their specific expression in HepG2 cells provided the basis for the targeted gene therapy of HCC.
    Title: Suicide gene therapy for hepatocellular carcinoma cells by survivin promoter-driven expression of the herpes simplex virus thymidine kinase gene.
  5. Through screening and characterization, it identified a thymidine analogue as a probe for imaging the expression of herpes simplex virus type-1 thymidine kinase (HSV1-TK).
    Title: Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression.
  6. In 56 HSV-1 strains, 26 different non-synonymous polymorphism-associated mutations were detected in the TK gene.
    Title: Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus.
  7. Acyclovir resistance was assigned to frameshift and single non-synonymous mutations of the thymidine kinase (TK) gene in 32 out of 37 HSV-1 strains.
    Title: Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.
  8. Data indicate that the combination of VEGF-A-silencing and tumor-specific expression of suicide gene is an effective strategy for colon carcinoma treatment.
    Title: Nanoparticle-delivered VEGF-silencing cassette and suicide gene expression cassettes inhibit colon carcinoma growth in vitro and in vivo.
  9. A thymidine kinase UL23 gene (EC 2.7.1.145) from an acyclovir-sensitive strain L2 of herpes simplex virus type 1 was cloned.
    Title: [Cloning, expression, isolation and properties of thymidine kinase herpes simplex virus, strain L2].
  10. The therapeutic effect of HSV1-tk/gancyclovir system in glioblastoma cells can be monitored using bioluminescent imaging and tumor size measurement.
    Title: Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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polyA_signal

  • Loc: c46613-46608
  • Loc: c46626-46621

General protein information

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Names
thymidine kinase
NP_044624.1

VOG classification

Description:

  • VOGd0074 [L] Herpesvirus thymidine kinase (similar to smaller deoxynucleoside kinases)
  • DNA Replication, Repair and Nucleotide Metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.1 Reference assembly

    Range
    46608..47911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_044624.1 thymidine kinase [Human herpesvirus 1]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1508243AA.1
BAA01669.1
KIBE17.1

Gene LinkOut

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