U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HGV1gp1 polyprotein precursor [ GB virus C ]

Gene ID: 2700757, updated on 18-Aug-2023

Summary

Go to the top of the page Help
Gene symbol
HGV1gp1
Gene description
polyprotein precursor
Locus tag
HGV1gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
GB virus C
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Pegivirus; Pegivirus C
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_001710.1 (459..9080)

NC_001710.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001710.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a peptide domain within the GB virus C envelope glycoprotein (E2) that inhibits HIV replication. Xiang J, et al. Virology, 2012 Aug 15. PMID 22608061, Free PMC Article
  2. GB virus type C interactions with HIV: the role of envelope glycoproteins. Mohr EL, et al. J Viral Hepat, 2009 Nov. PMID 19758271, Free PMC Article
  3. Characterization of a peptide domain within the GB virus C NS5A phosphoprotein that inhibits HIV replication. Xiang J, et al. PLoS One, 2008 Jul 2. PMID 18596910, Free PMC Article
  4. Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins. Belyaev AS, et al. J Virol, 1998 Jan. PMID 9420302, Free PMC Article
  5. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Linnen J, et al. Science, 1996 Jan 26. PMID 8560265

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NS3 protease of GB virus C cleaved MAVS but not TRIF, and it inhibited interferon responses sufficiently to enhance growth of an interferon-sensitive virus.
    Title: Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors.
  2. These data identify the region of GB virus C E2 protein involved in HIV inhibition, and suggest that this GB virus C E2 peptide must gain entry into the cell to inhibit HIV.
    Title: Characterization of a peptide domain within the GB virus C envelope glycoprotein (E2) that inhibits HIV replication.
  3. GBV-C E2-mediated HIV inhibition is dose-dependent and HIV replication is blocked at the binding and/or entry step.
    Title: GB virus type C interactions with HIV: the role of envelope glycoproteins.
  4. Expression of GBV-C NS5A amino acids 152-165 are sufficient to inhibit HIV replication in vitro, and the serine at position 158 appears important for this effect through either phosphorylation or structural changes in this peptide.
    Title: Characterization of a peptide domain within the GB virus C NS5A phosphoprotein that inhibits HIV replication.
Submit: New GeneRIF Correction

General protein information

Go to the top of the page Help
Preferred Names
polyprotein precursor
Names
putative E1 protein
putative E2 protein
putative protein p7-NS2
NS3 proteinase/ATPase/helicase
putative NS4A protein
putative NS4B protein
putative NS5A protein
putative NS5B RNA-dependent RNA polymerase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001710.1 Reference assembly

    Range
    459..9080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_043570.1 polyprotein precursor [GB virus C]

    See identical proteins and their annotated locations for NP_043570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P89967, Q69431
    Conserved Domains (12) summary
    pfam01001
    Location:1653 → 1847
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b
    pfam02907
    Location:955 → 1102
    Peptidase_S29; Hepatitis C virus NS3 protease
    pfam08301
    Location:1991 → 2089
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam12786
    Location:151 → 574
    GBV-C_env; GB virus C genotype envelope
    pfam01538
    Location:705 → 902
    HCV_NS2; Hepatitis C virus non-structural protein NS2
    smart00487
    Location:1123 → 1252
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:1123 → 1250
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:1278 → 1340
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00998
    Location:2313 → 2806
    RdRP_3; Viral RNA dependent RNA polymerase
    pfam01006
    Location:1554 → 1598
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    pfam01506
    Location:1897 → 1919
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:1927 → 1986
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

  2. NP_803202.1 putative E1 protein

    Conserved Domains (1) summary
    pfam12786
    Location:151 → 360
    GBV-C_env; GB virus C genotype envelope

  3. NP_803203.1 putative E2 protein

    UniProtKB/TrEMBL
    D3GMT8
    Conserved Domains (1) summary
    pfam12786
    Location:1 → 214
    GBV-C_env; GB virus C genotype envelope

  4. NP_803204.1 putative protein p7-NS2

    Conserved Domains (1) summary
    pfam01538
    Location:33 → 230
    HCV_NS2; Hepatitis C virus non-structural protein NS2

  5. NP_803205.1 NS3 proteinase/ATPase/helicase

    Conserved Domains (4) summary
    pfam02907
    Location:30 → 177
    Peptidase_S29; Hepatitis C virus NS3 protease
    smart00487
    Location:198 → 327
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:198 → 325
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:353 → 415
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

  6. NP_803206.1 putative NS4A protein

    Conserved Domains (1) summary
    pfam01006
    Location:3 → 38
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a

  7. NP_803207.1 putative NS4B protein

    Conserved Domains (1) summary
    pfam01001
    Location:36 → 230
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b

  8. NP_803208.1 putative NS5A protein

    UniProtKB/TrEMBL
    Q3LU44
    Conserved Domains (3) summary
    pfam08301
    Location:93 → 191
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam01506
    Location:1 → 21
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:29 → 88
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

  9. NP_803209.1 putative NS5B RNA-dependent RNA polymerase

    Conserved Domains (1) summary
    pfam00998
    Location:3 → 496
    RdRP_3; Viral RNA dependent RNA polymerase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.