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Pank4 pantothenate kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 269614, updated on 27-Nov-2024

Summary

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Official Symbol
Pank4provided by MGI
Official Full Name
pantothenate kinase 4provided by MGI
Primary source
MGI:MGI:2387466
See related
Ensembl:ENSMUSG00000029056 AllianceGenome:MGI:2387466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm42363; D030031I12Rik
Summary
Predicted to enable pantothenate kinase activity and phosphatase activity. Predicted to be involved in coenzyme A biosynthetic process and coenzyme A catabolic process. Predicted to be active in cytosol; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Used to study cataract. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 28.3), ovary adult (RPKM 20.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pank4 in Genome Data Viewer
Location:
4; 4 E2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155048580..155065395)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154964123..154980940)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12242 Neighboring gene tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Neighboring gene STARR-positive B cell enhancer ABC_E9628 Neighboring gene STARR-positive B cell enhancer ABC_E8039 Neighboring gene STARR-positive B cell enhancer ABC_E6295 Neighboring gene STARR-positive B cell enhancer ABC_E2149 Neighboring gene STARR-positive B cell enhancer ABC_E8040 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene phospholipase C, eta 2 Neighboring gene STARR-positive B cell enhancer ABC_E10295 Neighboring gene peroxisomal biogenesis factor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Dibble CC, et al. Nature, 2022 Aug. PMID 35896750, Free PMC Article
  2. A novel mutation of PANK4 causes autosomal dominant congenital posterior cataract. Sun M, et al. Hum Mutat, 2019 Apr. PMID 30585370
  3. Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine. Shibata K, et al. J Nutr, 1983 Oct. PMID 6619987
  4. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Zhou B, et al. Nat Genet, 2001 Aug. PMID 11479594
  5. Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. Sacksteder CA, et al. Biochemistry, 2006 Jul 4. PMID 16800626

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
4'-phosphopantetheine phosphatase
Names
inactive pantothenic acid kinase 4
pantothenic acid kinase 4
NP_001292733.1
NP_001392980.1
NP_001392981.1
NP_001392982.1
NP_001392983.1
NP_001392984.1
NP_001392985.1
NP_766578.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305804.2 → NP_001292733.1  4'-phosphopantetheine phosphatase isoform 1

    See identical proteins and their annotated locations for NP_001292733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX004788
    Consensus CDS
    CCDS84834.1
    UniProtKB/Swiss-Prot
    B1AZN5, B1AZN6, Q7M751, Q80YV4, Q8BQE9
    Related
    ENSMUSP00000064330.5, ENSMUST00000070953.11
    Conserved Domains (1) summary
    PLN02902
    Location:17 → 820
    PLN02902; pantothenate kinase

  2. NM_001406051.1 → NP_001392980.1  4'-phosphopantetheine phosphatase isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX004788

  3. NM_001406052.1 → NP_001392981.1  4'-phosphopantetheine phosphatase isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX004788

  4. NM_001406053.1 → NP_001392982.1  4'-phosphopantetheine phosphatase isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX004788

  5. NM_001406054.1 → NP_001392983.1  4'-phosphopantetheine phosphatase isoform 6

    Status: VALIDATED

    Source sequence(s)
    BX004788

  6. NM_001406055.1 → NP_001392984.1  4'-phosphopantetheine phosphatase isoform 7

    Status: VALIDATED

    Source sequence(s)
    BX004788

  7. NM_001406056.1 → NP_001392985.1  4'-phosphopantetheine phosphatase isoform 8

    Status: VALIDATED

    Source sequence(s)
    BX004788

  8. NM_172990.6 → NP_766578.2  4'-phosphopantetheine phosphatase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    BX004788
    Consensus CDS
    CCDS19019.1
    UniProtKB/Swiss-Prot
    Q80YV4
    Related
    ENSMUSP00000030931.5, ENSMUST00000030931.11
    Conserved Domains (1) summary
    PLN02902
    Location:17 → 773
    PLN02902; pantothenate kinase

RNA

  1. NR_131230.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK039866, AK050894, BC050089, BX004788, W87071

  2. NR_176003.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX004788

  3. NR_176004.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX004788

  4. NR_176005.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX004788

  5. NR_176006.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX004788
    Related
    ENSMUST00000148934.8

  6. NR_176007.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX004788

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155048580..155065395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YV4.2 GenPept UniProtKB/Swiss-Prot:Q80YV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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