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Sytl1 synaptotagmin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 269589, updated on 27-Nov-2024

Summary

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Official Symbol
Sytl1provided by MGI
Official Full Name
synaptotagmin-like 1provided by MGI
Primary source
MGI:MGI:1933365
See related
Ensembl:ENSMUSG00000028860 AllianceGenome:MGI:1933365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slp1; PSGL-1; 9030417L18
Summary
Enables neurexin family protein binding activity. Involved in exocytosis. Located in melanosome and plasma membrane. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human SYTL1 (synaptotagmin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 54.8), colon adult (RPKM 46.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Sytl1 in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132980401..132990398, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133253090..133263087, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CD164 sialomucin-like 2 Neighboring gene ficolin C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11620 Neighboring gene STARR-seq mESC enhancer starr_11622 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer mm9_chr4:132865900-132866201 Neighboring gene STARR-positive B cell enhancer ABC_E7995 Neighboring gene STARR-seq mESC enhancer starr_11626 Neighboring gene STARR-seq mESC enhancer starr_11627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. Ramadass M, et al. J Leukoc Biol, 2019 Jun. PMID 30748033, Free PMC Article
  2. The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Wang H, et al. Mol Biol Cell, 2013 Feb. PMID 23223571, Free PMC Article
  3. Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Saegusa C, et al. Arch Biochem Biophys, 2008 Jul 1. PMID 18477466
  4. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Johnson JL, et al. Mol Biol Cell, 2012 May. PMID 22438581, Free PMC Article
  5. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. Kurz AR, et al. J Clin Invest, 2016 Nov 1. PMID 27701149, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that defective Rac1-GTP recycling from the uropod affects directionality and highlight JFC1-mediated Rac1 trafficking as a potential target to regulate chemotaxis in inflammation and immunity.
    Title: The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration.
  2. Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
    Title: The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
  3. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
    Title: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
  4. Expression of Rab27B-binding proteinm Sytl1 in pancreatic acinar cells and its involvement in amylase secretion are reported.
    Title: Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion.
  5. Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
    Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7008

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurexin family protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in melanosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptotagmin-like protein 1
Names
exophilin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031393.2 → NP_113570.2  synaptotagmin-like protein 1

    See identical proteins and their annotated locations for NP_113570.2

    Status: VALIDATED

    Source sequence(s)
    AA856092, AI553427, AK131162
    Consensus CDS
    CCDS38902.1
    UniProtKB/Swiss-Prot
    Q99J26, Q99N80
    UniProtKB/TrEMBL
    A2AE94
    Related
    ENSMUSP00000030674.8, ENSMUST00000030674.8
    Conserved Domains (4) summary
    pfam06390
    Location:92 → 230
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd04020
    Location:405 → 561
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:273 → 392
    C2; C2 domain
    cl22851
    Location:35 → 99
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132980401..132990398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250265.1 → XP_011248567.1  synaptotagmin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011248567.1

    UniProtKB/Swiss-Prot
    Q99J26, Q99N80
    UniProtKB/TrEMBL
    A2AE94
    Conserved Domains (4) summary
    pfam06390
    Location:92 → 230
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd04020
    Location:405 → 561
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:273 → 392
    C2; C2 domain
    cl22851
    Location:35 → 99
    PHD_SF; PHD finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N80.2 GenPept UniProtKB/Swiss-Prot:Q99N80

Gene LinkOut

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