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Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon [ Mus musculus (house mouse) ]

Gene ID: 26932, updated on 27-Nov-2024

Summary

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Official Symbol
Ppp2r5eprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B', epsilonprovided by MGI
Primary source
MGI:MGI:1349473
See related
Ensembl:ENSMUSG00000021051 AllianceGenome:MGI:1349473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B56beta; 4633401M22Rik
Summary
Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and lung. Orthologous to human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.3), CNS E11.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp2r5e in Genome Data Viewer
Location:
12 C3; 12 32.75 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (75496237..75643064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (75449463..75596237, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member J Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76492550-76492789 Neighboring gene STARR-seq mESC enhancer starr_32491 Neighboring gene predicted gene, 34613 Neighboring gene glycoprotein hormone beta 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76550614-76550799 Neighboring gene STARR-seq mESC enhancer starr_32492 Neighboring gene STARR-seq mESC enhancer starr_32494 Neighboring gene STARR-seq mESC enhancer starr_32495 Neighboring gene STARR-positive B cell enhancer ABC_E2388 Neighboring gene predicted gene, 34666 Neighboring gene ribosomal protein lateral stalk subunit P2, pseudogene 1 Neighboring gene WD repeat domain 89

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B56beta, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching. Brandt N, et al. FASEB J, 2008 Jul. PMID 18385213
  2. p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Okamoto K, et al. Mol Cell Biol, 1996 Nov. PMID 8887688, Free PMC Article
  3. Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. Martens E, et al. J Mol Biol, 2004 Feb 27. PMID 15095873
  4. Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. Dyson JJ, et al. FASEB Bioadv, 2022 Apr. PMID 35415460, Free PMC Article
  5. Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development. Götz J, et al. Mech Dev, 2000 May. PMID 10781942

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 4633401M22Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Names
protein phosphatase 2A subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012024.3 → NP_036154.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

    See identical proteins and their annotated locations for NP_036154.1

    Status: VALIDATED

    Source sequence(s)
    AC124414, AK132432
    Consensus CDS
    CCDS25983.1
    UniProtKB/Swiss-Prot
    Q3V1I5, Q571M6, Q61151, Q8C2M2
    Related
    ENSMUSP00000021447.8, ENSMUST00000021447.9
    Conserved Domains (2) summary
    pfam01603
    Location:55 → 435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:2 → 67
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    75496237..75643064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515926.4 → XP_006515989.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2

    See identical proteins and their annotated locations for XP_006515989.1

    Conserved Domains (2) summary
    pfam01603
    Location:55 → 430
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:2 → 67
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. XM_006515925.4 → XP_006515988.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

    See identical proteins and their annotated locations for XP_006515988.1

    UniProtKB/Swiss-Prot
    Q3V1I5, Q571M6, Q61151, Q8C2M2
    Conserved Domains (2) summary
    pfam01603
    Location:55 → 435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:2 → 67
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_006515927.5 → XP_006515990.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3

    Conserved Domains (1) summary
    pfam01603
    Location:30 → 410
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61151.3 GenPept UniProtKB/Swiss-Prot:Q61151

Gene LinkOut

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