Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 26921, updated on 27-Nov-2024

Summary

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Official Symbol: Map4k4provided by MGI
Official Full Name: mitogen-activated protein kinase kinase kinase kinase 4provided by MGI
Primary source: MGI:MGI:1349394
See related: Ensembl:ENSMUSG00000026074 AllianceGenome:MGI:1349394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HGK; Nik; 9430080K19Rik
Summary: Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

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See Map4k4 in Genome Data Viewer

Location:: 1 B; 1 18.53 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (39939806..40065470)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (39900902..40026310)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
Title: Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
MAP4K4 is involved in the neuronal development of retinal photoreceptors.
Title: MAP4K4 is involved in the neuronal development of retinal photoreceptors.
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
Title: Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
These studies highlight a MAP4K4-initiated signaling cascade that induces motor neuron degeneration.
Title: MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis.
TLR4-MAP4K4 pathway can regulate retinal neovascularization.
Title: Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.
Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism.
Title: RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.
the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.
Title: FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.
Title: Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.
Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
Title: Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.
These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice.
Title: Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit212 (e-PCR), detects polymorphism
- UniSTS:128554

AU043147 (e-PCR)
- UniSTS:158786

AU045934 (e-PCR)
- UniSTS:158789

BB168363 (e-PCR)
- UniSTS:185435

NoName (e-PCR)
- UniSTS:234114

UniSTS:234115 (e-PCR)
- UniSTS:234115

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection regeneration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ARF protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of focal adhesion disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase kinase 4

Names: HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; NCK interacting kinase; nck-interacting kinase

NP_001239129.1

EC 2.7.11.1

NP_001239130.1

EC 2.7.11.1

NP_001239131.1

EC 2.7.11.1

NP_032722.2

EC 2.7.11.1

XP_006496104.1

EC 2.7.11.1

XP_006496105.1

EC 2.7.11.1

XP_006496106.1

EC 2.7.11.1

XP_006496108.1

EC 2.7.11.1

XP_006496109.1

EC 2.7.11.1

XP_011236832.1

EC 2.7.11.1

XP_017176483.1

EC 2.7.11.1

XP_017176487.1

EC 2.7.11.1

XP_017176490.1

EC 2.7.11.1

XP_017176491.1

EC 2.7.11.1

XP_017176493.1

EC 2.7.11.1

XP_017176499.1

EC 2.7.11.1

XP_017176500.1

EC 2.7.11.1

XP_017176502.1

EC 2.7.11.1

XP_017176507.1

EC 2.7.11.1

XP_017176510.1

EC 2.7.11.1

XP_030110570.1

EC 2.7.11.1

XP_030110580.1

EC 2.7.11.1

XP_036021388.1

EC 2.7.11.1

XP_036021391.1

EC 2.7.11.1

XP_036021394.1

EC 2.7.11.1

XP_036021398.1

EC 2.7.11.1

XP_036021400.1

EC 2.7.11.1

XP_036021407.1

EC 2.7.11.1

XP_036021415.1

EC 2.7.11.1

XP_036021418.1

EC 2.7.11.1

XP_036021421.1

EC 2.7.11.1

XP_036021424.1

EC 2.7.11.1

XP_036021426.1

EC 2.7.11.1

XP_036021430.1

EC 2.7.11.1

XP_036021432.1

EC 2.7.11.1

XP_036021435.1

EC 2.7.11.1

XP_036021436.1

EC 2.7.11.1

XP_036021440.1

EC 2.7.11.1

XP_036021441.1

EC 2.7.11.1

XP_036021442.1

EC 2.7.11.1

XP_036021443.1

EC 2.7.11.1

XP_036021445.1

EC 2.7.11.1

XP_036021446.1

EC 2.7.11.1

XP_036021449.1

EC 2.7.11.1

XP_036021450.1

EC 2.7.11.1

XP_036021454.1

EC 2.7.11.1

XP_036021456.1

EC 2.7.11.1

XP_036021458.1

EC 2.7.11.1

XP_036021460.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252200.1 → NP_001239129.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK159799, AV445090, BB651050, BC145390, BF721981, BQ571658, CJ142598, U88984

Consensus CDS

CCDS78573.1

UniProtKB/TrEMBL

A0A0A6YW53, B7ZNR8

Related

ENSMUSP00000141400.2, ENSMUST00000195860.6

Conserved Domains (3) summary

smart00036
Location:970 → 1268

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
NM_001252201.1 → NP_001239130.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

See identical proteins and their annotated locations for NP_001239130.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the presence and absence of in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.

Source sequence(s)

AK159799, AV445090, BB651050, BC141109, BC145390, BF721981, BQ571658, CJ142598, U88984

Consensus CDS

CCDS78576.1

UniProtKB/Swiss-Prot

P97820

UniProtKB/TrEMBL

B2RUE8

Related

ENSMUSP00000141862.2, ENSMUST00000193682.6

Conserved Domains (3) summary

smart00036
Location:903 → 1201

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
NM_001252202.1 → NP_001239131.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

See identical proteins and their annotated locations for NP_001239131.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (4), compared to isoform 1.

Source sequence(s)

AK159799, AV445090, BB651050, BC145390, BC145391, BF721981, BQ571658, CJ142598, U88984

Consensus CDS

CCDS78575.1

UniProtKB/TrEMBL

B7ZNR9, F8VPL5

Related

ENSMUSP00000142056.2, ENSMUST00000195259.6

Conserved Domains (3) summary

smart00036
Location:890 → 1188

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
NM_008696.2 → NP_032722.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

See identical proteins and their annotated locations for NP_032722.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AC132909, AC166238, AK138966, CF531764, U88984

Consensus CDS

CCDS35546.1

UniProtKB/Swiss-Prot

P97820

UniProtKB/TrEMBL

A0A0A6YWR8

Related

ENSMUSP00000141665.2, ENSMUST00000192509.6

Conserved Domains (3) summary

smart00036
Location:916 → 1214

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

39939806..40065470

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496041.3 → XP_006496104.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1065 → 1363

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_011238530.3 → XP_011236832.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1001 → 1299

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321001.3 → XP_017176490.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

UniProtKB/TrEMBL

E9PVG7

Conserved Domains (2) summary

smart00036
Location:1062 → 1360

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321010.3 → XP_017176499.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

UniProtKB/TrEMBL

E9PVG7

Conserved Domains (2) summary

smart00036
Location:998 → 1296

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017320994.3 → XP_017176483.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1064 → 1362

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017320998.3 → XP_017176487.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1063 → 1361

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165495.1 → XP_036021388.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1062 → 1360

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321011.3 → XP_017176500.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:988 → 1286

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165549.1 → XP_036021442.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:924 → 1222

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165525.1 → XP_036021418.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:985 → 1283

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165522.1 → XP_036021415.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:987 → 1285

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_006496042.3 → XP_006496105.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

UniProtKB/TrEMBL

Q6ZQ68

Conserved Domains (2) summary

smart00036
Location:1011 → 1309

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165537.1 → XP_036021430.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:947 → 1245

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_030254710.2 → XP_030110570.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

UniProtKB/TrEMBL

Q6ZQ68

Conserved Domains (2) summary

smart00036
Location:1010 → 1308

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165539.1 → XP_036021432.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:946 → 1244

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321004.3 → XP_017176493.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

UniProtKB/TrEMBL

Q6ZQ68

Conserved Domains (2) summary

smart00036
Location:1009 → 1307

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165542.1 → XP_036021435.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:945 → 1243

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165514.1 → XP_036021407.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

UniProtKB/TrEMBL

Q6ZQ68

Conserved Domains (2) summary

smart00036
Location:1008 → 1306

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165543.1 → XP_036021436.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:944 → 1242

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321018.3 → XP_017176507.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:934 → 1232

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165557.1 → XP_036021450.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:870 → 1168

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321021.3 → XP_017176510.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:931 → 1229

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165563.1 → XP_036021456.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:867 → 1165

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165547.1 → XP_036021440.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:933 → 1231

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165561.1 → XP_036021454.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:869 → 1167

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165548.1 → XP_036021441.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:930 → 1228

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321002.3 → XP_017176491.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1034 → 1332

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165505.1 → XP_036021398.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

UniProtKB/TrEMBL

E9PVG7

Conserved Domains (2) summary

smart00036
Location:1031 → 1329

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165533.1 → XP_036021426.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

UniProtKB/TrEMBL

E9PVG7

Related

ENSMUSP00000126961.3, ENSMUST00000163854.9

Conserved Domains (2) summary

smart00036
Location:967 → 1265

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165498.1 → XP_036021391.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1033 → 1331

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165501.1 → XP_036021394.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

UniProtKB/TrEMBL

B7ZNR8

Conserved Domains (2) summary

smart00036
Location:1032 → 1330

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165507.1 → XP_036021400.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

UniProtKB/TrEMBL

E9PVG7

Conserved Domains (2) summary

smart00036
Location:1029 → 1327

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_006496045.3 → XP_006496108.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

UniProtKB/TrEMBL

F8VPL5

Conserved Domains (2) summary

smart00036
Location:893 → 1191

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_006496043.3 → XP_006496106.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

UniProtKB/TrEMBL

A0A0A6YWM8, F8VPL5

Related

ENSMUSP00000141613.2, ENSMUST00000195636.6

Conserved Domains (2) summary

smart00036
Location:954 → 1252

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_017321013.3 → XP_017176502.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:980 → 1278

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_030254720.2 → XP_030110580.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:977 → 1275

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165552.1 → XP_036021445.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:913 → 1211

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165528.1 → XP_036021421.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:979 → 1277

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165550.1 → XP_036021443.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:915 → 1213

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165531.1 → XP_036021424.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:976 → 1274

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165565.1 → XP_036021458.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:839 → 1137

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165556.1 → XP_036021449.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:900 → 1198

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165567.1 → XP_036021460.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:836 → 1134

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_036165553.1 → XP_036021446.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:902 → 1200

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain
XM_006496046.3 → XP_006496109.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

UniProtKB/Swiss-Prot

P97820

Conserved Domains (2) summary

smart00036
Location:838 → 1136

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:8 → 289

PKc_like; Protein Kinases, catalytic domain