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Stk36 serine/threonine kinase 36 [ Mus musculus (house mouse) ]

Gene ID: 269209, updated on 27-Nov-2024

Summary

Official Symbol
Stk36provided by MGI
Official Full Name
serine/threonine kinase 36provided by MGI
Primary source
MGI:MGI:1920831
See related
Ensembl:ENSMUSG00000033276 AllianceGenome:MGI:1920831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FU; Fused; mKIAA1278; B930045J24; 1700112N14Rik
Summary
Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Involved in several processes, including cilium assembly; positive regulation of smoothened signaling pathway; and smoothened signaling pathway. Acts upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Located in cytoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; tail somite; and testis. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 49.4), whole brain E14.5 (RPKM 6.3) and 6 other tissues See more
Orthologs
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Genomic context

See Stk36 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74640583..74676053)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74601391..74636894)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene tubulin tyrosine ligase-like family, member 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1278, MGC58023

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 36
Names
fused homolog
serine/threonine kinase 36 (fused homolog, Drosophila)
NP_001391006.1
NP_001391007.1
NP_778196.2
XP_036021382.1
XP_036021383.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404077.1NP_001391006.1  serine/threonine-protein kinase 36 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117610
  2. NM_001404078.1NP_001391007.1  serine/threonine-protein kinase 36 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Related
    ENSMUSP00000084433.5, ENSMUST00000087186.11
  3. NM_175031.4NP_778196.2  serine/threonine-protein kinase 36 isoform 1

    See identical proteins and their annotated locations for NP_778196.2

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Consensus CDS
    CCDS35619.1
    UniProtKB/Swiss-Prot
    Q69ZM6, Q6PDI0, Q80XQ6
    Related
    ENSMUSP00000084430.5, ENSMUST00000087183.11
    Conserved Domains (2) summary
    smart00220
    Location:4254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RNA

  1. NR_175802.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610
  2. NR_175803.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Related
    ENSMUST00000145673.8
  3. NR_175804.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610
  4. NR_175805.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74640583..74676053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165489.1XP_036021382.1  serine/threonine-protein kinase 36 isoform X2

    Conserved Domains (1) summary
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
  2. XM_036165490.1XP_036021383.1  serine/threonine-protein kinase 36 isoform X3

    Conserved Domains (4) summary
    COG1413
    Location:9071152
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:962989
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:10281123
    HEAT_2; HEAT repeats
    cl21453
    Location:10118
    PKc_like; Protein Kinases, catalytic domain