Colgalt2 collagen beta(1-O)galactosyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Colgalt2provided by MGI
Official Full Name: collagen beta(1-O)galactosyltransferase 2provided by MGI
Primary source: MGI:MGI:2138232
See related: Ensembl:ENSMUSG00000032649 AllianceGenome:MGI:2138232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glt25d2; D730024P12
Summary: Predicted to enable procollagen galactosyltransferase activity. Predicted to be located in endoplasmic reticulum lumen. Is expressed in axial skeleton; central nervous system; and retina. Orthologous to human COLGALT2 (collagen beta(1-O)galactosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 5.4), limb E14.5 (RPKM 4.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G2; 1 64.77 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (152275485..152386942)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (152399805..152510695)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI427652 (e-PCR)
- UniSTS:178478

Glt25d2 (e-PCR), detects polymorphism
- UniSTS:546795

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables procollagen galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen galactosyltransferase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: procollagen galactosyltransferase 2

Names: glycosyltransferase 25 domain containing 2; glycosyltransferase 25 family member 2; hydroxylysine galactosyltransferase 2

NP_001408051.1

EC 2.4.1.50

NP_808424.3

EC 2.4.1.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421122.1 → NP_001408051.1 procollagen galactosyltransferase 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC123732
NM_177756.5 → NP_808424.3 procollagen galactosyltransferase 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_808424.3

Status: VALIDATED

Source sequence(s)

AC123732

Consensus CDS

CCDS15364.1

UniProtKB/Swiss-Prot

Q6NVG7, Q8BWD4

Related

ENSMUSP00000037532.9, ENSMUST00000044311.9

Conserved Domains (2) summary

pfam13704
Location:61 → 174

Glyco_tranf_2_4; Glycosyl transferase family 2

cl01298
Location:340 → 525

Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...