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Samd3 sterile alpha motif domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 268288, updated on 4-Jan-2025

Summary

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Official Symbol
Samd3provided by MGI
Official Full Name
sterile alpha motif domain containing 3provided by MGI
Primary source
MGI:MGI:2685469
See related
Ensembl:ENSMUSG00000051354 AllianceGenome:MGI:2685469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm623
Summary
Is expressed in face; nervous system; skeleton; and tail. Orthologous to human SAMD3 (sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Samd3 in Genome Data Viewer
Location:
10 A4; 10 13.57 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26105465..26148814)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26229616..26272916)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 200A Neighboring gene predicted gene 9767 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26120 Neighboring gene STARR-seq mESC enhancer starr_26121 Neighboring gene L3MBTL3 histone methyl-lysine binding protein Neighboring gene STARR-seq mESC enhancer starr_26122 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A multifunctional mouse model to study the role of Samd3. Peters AE, et al. Eur J Immunol, 2022 Feb. PMID 34626120
  2. Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells. Kashiwagi I, et al. Immunity, 2015 Jul 21. PMID 26141582
  3. Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent. Quintana-Urzainqui I, et al. iScience, 2018 Dec 21. PMID 30529950, Free PMC Article
  4. Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Moreau MX, et al. Development, 2021 Jul 15. PMID 34170322
  5. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A multifunctional mouse model to study the role of Samd3.
    Title: A multifunctional mouse model to study the role of Samd3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
sterile alpha motif domain-containing protein 3
Names
SAM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013766.3 → NP_001013788.2  sterile alpha motif domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091763
    Consensus CDS
    CCDS48524.1
    UniProtKB/TrEMBL
    B9EKF8
    Related
    ENSMUSP00000129054.2, ENSMUST00000164660.8
    Conserved Domains (2) summary
    cd09526
    Location:1 → 66
    SAM_Samd3; SAM domain of Samd3 subfamily
    smart00454
    Location:1 → 65
    SAM; Sterile alpha motif

  2. NM_001115154.2 → NP_001108626.1  sterile alpha motif domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091763
    Consensus CDS
    CCDS48525.1
    UniProtKB/Swiss-Prot
    E9QPH5, Q8C4H2
    UniProtKB/TrEMBL
    E9Q3G4
    Related
    ENSMUSP00000057805.6, ENSMUST00000060716.6
    Conserved Domains (2) summary
    cd09526
    Location:1 → 66
    SAM_Samd3; SAM domain of Samd3 subfamily
    smart00454
    Location:1 → 65
    SAM; Sterile alpha motif

  3. NM_001408265.1 → NP_001395194.1  sterile alpha motif domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091763

  4. NM_001408266.1 → NP_001395195.1  sterile alpha motif domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091763

  5. NM_001408267.1 → NP_001395196.1  sterile alpha motif domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC091763

  6. NM_001408268.1 → NP_001395197.1  sterile alpha motif domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091763
    UniProtKB/TrEMBL
    B9EKF8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    26105465..26148814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512743.4 → XP_006512806.1  sterile alpha motif domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    E9QPH5, Q8C4H2
    Conserved Domains (1) summary
    cd09526
    Location:28 → 93
    SAM_Samd3; SAM domain of Samd3 subfamily

  2. XM_006512742.4 → XP_006512805.1  sterile alpha motif domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    E9QPH5, Q8C4H2
    Conserved Domains (1) summary
    cd09526
    Location:14 → 79
    SAM_Samd3; SAM domain of Samd3 subfamily

  3. XM_006512744.3 → XP_006512807.1  sterile alpha motif domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006512807.1

    UniProtKB/Swiss-Prot
    E9QPH5, Q8C4H2
    Conserved Domains (1) summary
    cl15755
    Location:1 → 25
    SAM_superfamily; SAM (Sterile alpha motif )

  4. XM_011243173.3 → XP_011241475.1  sterile alpha motif domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011241475.1

    UniProtKB/Swiss-Prot
    E9QPH5, Q8C4H2
    Conserved Domains (1) summary
    cl15755
    Location:1 → 25
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4H2.3 GenPept UniProtKB/Swiss-Prot:Q8C4H2

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