neo1a neogenin 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: neo1aprovided by ZNC
Official Full Name: neogenin 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021031-1
See related: Ensembl:ENSDARG00000102855 AllianceGenome:ZFIN:ZDB-GENE-021031-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: neo1; cb333; zneo1; zgc:109795
Summary: Acts upstream of or within cell morphogenesis; neural tube formation; and somitogenesis. Predicted to be located in membrane. Predicted to be active in axonal growth cone; cell surface; and plasma membrane. Is expressed in several structures, including nervous system; neural rod; pectoral fin; pleuroperitoneal region; and splanchnocranium. Orthologous to human NEO1 (neogenin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (53754653..54089325)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (53485001..53819673)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We reveal that Rgma-Neo1 signaling controls neuroepithelial cel elongation independently of the establishment of apical junctional complexes and identify Rgma-induced Neo1 proteolytic cleavage as a key upstream signaling event
Title: Rgma-Induced Neo1 Proteolysis Promotes Neural Tube Morphogenesis.
Alternative splicing generates several isoforms of zneo1, most of which are developmentally regulated, showing distinct distribution in brain and other tissues
Title: Cloning, expression, and alternative splicing of neogenin1 in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neogenin 1a

Names: neogenin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328497.1 → NP_001315426.1 neogenin 1a isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL935050, BX927325, BX927344, CU463832

UniProtKB/TrEMBL

A0A0R4IIB3, A0A8M1P4Y3

Related

ENSDARP00000135352.2, ENSDART00000163261.2

Conserved Domains (8) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:244 → 307

IGc2; Immunoglobulin C-2 Type

cd05723
Location:337 → 407

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:718 → 797

FN3; Fibronectin type 3 domain

smart00410
Location:40 → 129

IG_like; Immunoglobulin like

cd00063
Location:420 → 512

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 316

I-set; Immunoglobulin I-set domain

pfam06583
Location:1116 → 1409

Neogenin_C; Neogenin C-terminus
NM_173218.2 → NP_775325.2 neogenin 1a isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL935050, BX927325, BX927344, CU463832

UniProtKB/TrEMBL

A0A0R4IP15, A0A8M1PBU5

Related

ENSDARP00000137310.1, ENSDART00000158160.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

53754653..54089325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009303464.4 → XP_009301739.1 neogenin 1a isoform X1

UniProtKB/TrEMBL

A0A8M3AUL1

Conserved Domains (8) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:244 → 307

IGc2; Immunoglobulin C-2 Type

cd05723
Location:337 → 407

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:740 → 819

FN3; Fibronectin type 3 domain

smart00410
Location:40 → 129

IG_like; Immunoglobulin like

cd00063
Location:442 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 316

I-set; Immunoglobulin I-set domain

pfam06583
Location:1157 → 1450

Neogenin_C; Neogenin C-terminus
XM_017356809.3 → XP_017212298.1 neogenin 1a isoform X7

UniProtKB/TrEMBL

A0A8M6YZX3
XM_009303468.4 → XP_009301743.1 neogenin 1a isoform X8

UniProtKB/TrEMBL

A0A8M3B4F0

Conserved Domains (9) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:244 → 307

IGc2; Immunoglobulin C-2 Type

cd05723
Location:337 → 407

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:740 → 819

FN3; Fibronectin type 3 domain

smart00410
Location:40 → 129

IG_like; Immunoglobulin like

cd00063
Location:442 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 316

I-set; Immunoglobulin I-set domain

pfam06583
Location:1157 → 1366

Neogenin_C; Neogenin C-terminus

cl11960
Location:134 → 220

Ig; Immunoglobulin domain
XM_009303466.4 → XP_009301741.1 neogenin 1a isoform X3

UniProtKB/TrEMBL

A0A8M3AUJ2

Conserved Domains (8) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:244 → 307

IGc2; Immunoglobulin C-2 Type

cd05723
Location:337 → 407

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:740 → 819

FN3; Fibronectin type 3 domain

smart00410
Location:40 → 129

IG_like; Immunoglobulin like

cd00063
Location:442 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 316

I-set; Immunoglobulin I-set domain

pfam06583
Location:1146 → 1439

Neogenin_C; Neogenin C-terminus
XM_005166588.4 → XP_005166645.1 neogenin 1a isoform X4

UniProtKB/TrEMBL

A0A8M2BE14

Conserved Domains (8) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:244 → 307

IGc2; Immunoglobulin C-2 Type

cd05723
Location:337 → 407

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:740 → 819

FN3; Fibronectin type 3 domain

smart00410
Location:40 → 129

IG_like; Immunoglobulin like

cd00063
Location:442 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 316

I-set; Immunoglobulin I-set domain

pfam06583
Location:1138 → 1431

Neogenin_C; Neogenin C-terminus
XM_009303465.4 → XP_009301740.1 neogenin 1a isoform X2

UniProtKB/TrEMBL

A0A8M3BBA1

Conserved Domains (8) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:244 → 306

IGc2; Immunoglobulin C-2 Type

cd05723
Location:336 → 406

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:739 → 818

FN3; Fibronectin type 3 domain

smart00410
Location:40 → 129

IG_like; Immunoglobulin like

cd00063
Location:441 → 533

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 315

I-set; Immunoglobulin I-set domain

pfam06583
Location:1156 → 1449

Neogenin_C; Neogenin C-terminus
XM_068222155.1 → XP_068078256.1 neogenin 1a isoform X5
XM_021477387.2 → XP_021333062.1 neogenin 1a isoform X6

UniProtKB/TrEMBL

A0A8M9PNJ2

Conserved Domains (7) summary

cd05722
Location:35 → 129

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

cd05723
Location:337 → 407

Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00060
Location:740 → 819

FN3; Fibronectin type 3 domain

smart00409
Location:143 → 220

IG; Immunoglobulin

cd00063
Location:442 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:231 → 316

I-set; Immunoglobulin I-set domain

pfam06583
Location:1157 → 1423

Neogenin_C; Neogenin C-terminus