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pamn-1 putative peptidylglycine alpha-hydroxylating monooxygenase [ Caenorhabditis elegans ]

Gene ID: 266833, updated on 4-Jan-2025

Summary

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Official Symbol
pamn-1
Official Full Name
putative peptidylglycine alpha-hydroxylating monooxygenase
Primary source
WormBase:WBGene00020556
Locus tag
CELE_T19B4.1
See related
AllianceGenome:WB:WBGene00020556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable copper ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Predicted to be involved in peptide metabolic process. Predicted to be located in membrane. Predicted to be active in extracellular region. Is expressed in intestine and nervous system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pamn-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (5702156..5705553)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase Neighboring gene Netrin receptor unc-40 Neighboring gene RanBP2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LIM/homeobox protein lim-7 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. Ramirez-Suarez NJ, et al. Dev Cell, 2019 Jan 28. PMID 30661986, Free PMC Article
  2. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidylamidoglycolate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidylglycine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative peptidylglycine alpha-hydroxylating monooxygenase
NP_001367424.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5702156..5705553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380351.3 → NP_001367424.1  putative peptidylglycine alpha-hydroxylating monooxygenase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83388, P91458
    Conserved Domains (3) summary
    cd14958
    Location:355 → 656
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:61 → 146
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:168 → 289
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83388.2

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