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lin-59 putative histone-lysine N-methyltransferase lin-59 [ Caenorhabditis elegans ]

Gene ID: 266825, updated on 9-Dec-2024

Summary

Official Symbol
lin-59
Official Full Name
putative histone-lysine N-methyltransferase lin-59
Primary source
WormBase:WBGene00003040
Locus tag
CELE_T12F5.4
See related
AllianceGenome:WB:WBGene00003040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3K36 methyltransferase activity. Involved in several processes, including ectodermal cell fate specification; egg-laying behavior; and nematode male tail tip morphogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in hypodermis; intestine; muscle cell; and neurons. Used to study leukemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See lin-59 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (3713449..3721157, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene pre-microRNA mir-8204 Neighboring gene PRELI/MSF1 domain-containing protein Neighboring gene ATP-dependent RNA helicase glh-4 Neighboring gene RING-type domain-containing protein Neighboring gene HTH La-type RNA-binding domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K36 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative histone-lysine N-methyltransferase lin-59
NP_491206.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3713449..3721157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058805.8NP_491206.1  putative histone-lysine N-methyltransferase lin-59 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44757
    Conserved Domains (4) summary
    smart00570
    Location:591636
    AWS; associated with SET domains
    smart00317
    Location:638748
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd04717
    Location:11181222
    BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
    pfam00628
    Location:9701027
    PHD; PHD-finger