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csk-1 Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1 [ Caenorhabditis elegans ]

Gene ID: 266817, updated on 4-Jan-2025

Summary

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Official Symbol
csk-1
Official Full Name
Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1
Primary source
WormBase:WBGene00000812
Locus tag
CELE_Y48G1C.2
See related
AllianceGenome:WB:WBGene00000812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein tyrosine kinase activity. Involved in several processes, including larval feeding behavior; nematode larval development; and nematode pharyngeal pumping. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including anus; head neurons; hermaphrodite somatic gonadal cell; pharyngeal muscle cell; and vulval cell. Orthologous to several human genes including CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See csk-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (71425..81061)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Myotubularin phosphatase domain-containing protein Neighboring gene HTH CENPB-type domain-containing protein Neighboring gene Sm domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans. Takata N, et al. Genes Cells, 2009 Mar. PMID 19210548
  2. Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans. Hirose T, et al. FEBS Lett, 2003 Jan 16. PMID 12527374
  3. Caenorhabditis elegans fibroblast growth factor receptor signaling can occur independently of the multi-substrate adaptor FRS2. Lo TW, et al. Genetics, 2010 Jun. PMID 20308281, Free PMC Article
  4. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Shirayama M, et al. Curr Biol, 2006 Jan 10. PMID 16343905
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that CSK-1 has an essential function in organization of pharyngeal muscle filaments that does not require C. elegans Src family tyrosine kinases.
    Title: Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.
  2. results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1
    Title: Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1
NP_001293162.1
  • Partially confirmed by transcript evidence
NP_001293163.1
  • Confirmed by transcript evidence
NP_001379977.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    71425..81061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306233.3 → NP_001293162.1  Tyrosine-protein kinase csk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293162.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECJ6
    Conserved Domains (2) summary
    cd09937
    Location:232 → 330
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd05039
    Location:362 → 620
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  2. NM_001392355.1 → NP_001379977.1  Tyrosine-protein kinase csk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECJ6, V6CL92
    Conserved Domains (2) summary
    cd09937
    Location:147 → 245
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd05039
    Location:277 → 535
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  3. NM_001306234.3 → NP_001293163.1  Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CL68
    Conserved Domains (1) summary
    cl21453
    Location:1 → 39
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECJ6.1

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