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sec61a1b SEC61 translocon subunit alpha 1b [ Danio rerio (zebrafish) ]

Gene ID: 266796, updated on 9-Dec-2024

Summary

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Official Symbol
sec61a1bprovided by ZNC
Official Full Name
SEC61 translocon subunit alpha 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021016-2
See related
Ensembl:ENSDARG00000005675 AllianceGenome:ZFIN:ZDB-GENE-021016-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb413; sec61b; sec61a1l; sec61al2; wu:fb36f05; wu:fb36f12; wu:fb37d04; wu:fi26f11
Summary
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Acts upstream of or within pronephros development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including EVL; anterior axial hypoblast; axis; ectoderm; and mesoderm. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See sec61a1b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (42377911..42388579, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (42380375..42391043, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ER membrane protein complex subunit 3 Neighboring gene inositol hexakisphosphate kinase 2a Neighboring gene macrophage stimulating 1 receptor a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia. Bolar NA, et al. Am J Hum Genet, 2016 Jul 7. PMID 27392076, Free PMC Article
  2. XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Hu MC, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17560942
  3. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
  4. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein transport protein Sec61 subunit alpha-like 2
Names
SEC61 translocon alpha 1 subunit, like
SEC61 translocon subunit alpha 1, like
SEC61, beta subunit
Sec61 alpha like 2
transport protein Sec61 subunit alpha like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201577.1 → NP_963871.1  protein transport protein Sec61 subunit alpha-like 2

    See identical proteins and their annotated locations for NP_963871.1

    Status: PROVISIONAL

    Source sequence(s)
    AY034614
    UniProtKB/Swiss-Prot
    Q7ZUL2, Q90YL4
    UniProtKB/TrEMBL
    A0A0J9YIG5
    Related
    ENSDARP00000049424.6, ENSDART00000049425.7
    Conserved Domains (3) summary
    PTZ00219
    Location:1 → 471
    PTZ00219; Sec61 alpha subunit; Provisional
    pfam00344
    Location:75 → 458
    SecY; SecY translocase
    pfam10559
    Location:40 → 73
    Plug_translocon; Plug domain of Sec61p

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    42377911..42388579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90YL4.3 GenPept UniProtKB/Swiss-Prot:Q90YL4

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