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Parg poly (ADP-ribose) glycohydrolase [ Mus musculus (house mouse) ]

Gene ID: 26430, updated on 27-Nov-2024

Summary

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Official Symbol
Pargprovided by MGI
Official Full Name
poly (ADP-ribose) glycohydrolaseprovided by MGI
Primary source
MGI:MGI:1347094
See related
Ensembl:ENSMUSG00000021911 AllianceGenome:MGI:1347094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables poly(ADP-ribose) glycohydrolase activity. Acts upstream of or within DNA damage response and detection of bacterium. Located in cytosol and nucleus. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Parg in Genome Data Viewer
Location:
14 19.4 cM; 14 B
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31923900..32020671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32201930..32298714)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 4 Neighboring gene STARR-seq mESC enhancer starr_36340 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946 Neighboring gene STARR-positive B cell enhancer mm9_chr14:33042212-33042513 Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36341 Neighboring gene predicted gene, 48914 Neighboring gene oxoglutarate dehydrogenase-like Neighboring gene predicted gene, 52134 Neighboring gene RIKEN cDNA 1700024G13 gene Neighboring gene STARR-seq mESC enhancer starr_36344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. Wang Z, et al. PLoS One, 2014. PMID 24465839, Free PMC Article
  2. Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Koh DW, et al. Proc Natl Acad Sci U S A, 2004 Dec 21. PMID 15591342, Free PMC Article
  3. Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury. Patel NS, et al. J Am Soc Nephrol, 2005 Mar. PMID 15677308
  4. PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment. Johnson S, et al. BMC Cancer, 2022 May 18. PMID 35585513, Free PMC Article
  5. The road to survival goes through PARG. Koh DW, et al. Cell Cycle, 2005 Mar. PMID 15725727

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. O-GlcNAc has crosstalk with ADP-ribosylation via PARG.
    Title: O-GlcNAc has crosstalk with ADP-ribosylation via PARG.
  2. Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells.
    Title: Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells.
  3. Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase.
    Title: Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase.
  4. PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment.
    Title: PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment.
  5. Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis.
    Title: Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis.
  6. PPARgamma deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
    Title: PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
  7. the results of the present study imply that PARG could serve an important role in the growth of tumours and metastasis to the liver of colon carcinoma and may serve as a new target for clinical colon carcinoma therapy.
    Title: PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF‑κB in tumour metastases of colon carcinoma.
  8. This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.
    Title: Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.
  9. PARG110 knockout retinal explants were highly resistant to cyclic GMP toxicity.
    Title: Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.
  10. we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.
    Title: Expression of poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(ADP-ribose) glycohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(ADP-ribose) glycohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
  
involved_in ATP generation from poly-ADP-D-ribose ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(ADP-ribose) glycohydrolase
Names
cytosolic poly(ADP-ribose) glycohydrolase
NP_001346844.1
NP_001361150.1
NP_036090.2
XP_030103682.1
XP_030103683.1
XP_036014496.1
XP_036014497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359915.1 → NP_001346844.1  poly(ADP-ribose) glycohydrolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167565, AI450246, AK080306, BC053037, BC059827
    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:491 → 816
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  2. NM_001374221.1 → NP_001361150.1  poly(ADP-ribose) glycohydrolase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532, AC167565
    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:468 → 793
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  3. NM_011960.3 → NP_036090.2  poly(ADP-ribose) glycohydrolase isoform 1

    See identical proteins and their annotated locations for NP_036090.2

    Status: VALIDATED

    Source sequence(s)
    AC167565, AI450246, BC053037, BC059827
    Consensus CDS
    CCDS36865.1
    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    UniProtKB/TrEMBL
    G3X8U8
    Related
    ENSMUSP00000022470.9, ENSMUST00000022470.15
    Conserved Domains (1) summary
    pfam05028
    Location:574 → 902
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31923900..32020671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158604.1 → XP_036014497.1  poly(ADP-ribose) glycohydrolase isoform X3

    UniProtKB/TrEMBL
    A0A2I3BRU5
    Related
    ENSMUSP00000154704.2, ENSMUST00000164137.8
    Conserved Domains (2) summary
    pfam05028
    Location:574 → 682
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    NF033845
    Location:171 → 346
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  2. XM_036158603.1 → XP_036014496.1  poly(ADP-ribose) glycohydrolase isoform X1

    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:491 → 816
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  3. XM_030247822.2 → XP_030103682.1  poly(ADP-ribose) glycohydrolase isoform X1

    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:491 → 816
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  4. XM_030247823.2 → XP_030103683.1  poly(ADP-ribose) glycohydrolase isoform X2

    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:468 → 793
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88622.2 GenPept UniProtKB/Swiss-Prot:O88622

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