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mt-Cytb cytochrome b, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 26192, updated on 14-Nov-2024

Summary

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Official Symbol
mt-Cytbprovided by RGD
Official Full Name
cytochrome b, mitochondrialprovided by RGD
Primary source
RGD:620081
See related
AllianceGenome:RGD:620081
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CYTB
Summary
Predicted to enable metal ion binding activity. Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Involved in several processes, including electron transport coupled proton transport; response to cobalamin; and response to glucagon. Located in mitochondrial inner membrane. Part of protein-containing complex. Biomarker of thyrotoxicosis; type 2 diabetes mellitus; and visual epilepsy. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mt-Cytb in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (14136..15278)
106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (14136..15278)

Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 5 Neighboring gene NADH dehydrogenase subunit 6 Neighboring gene tRNA-Glu Neighboring gene tRNA-Thr Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sites of inhibition of mitochondrial electron transport by cadmium. Miccadei S, et al. Chem Biol Interact, 1993 Dec. PMID 8269544
  2. Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. Vlessis AA, et al. J Neurochem, 1990 Apr. PMID 2313294
  3. Changes in rat liver cytochromes b, c1, and c and mitochondrial protein in prolonged protein deficiency. Williams JN Jr, et al. J Nutr, 1966 Dec. PMID 5954822
  4. Effect of experimental thyrotoxicosis on oxidative phosphorylation in rat liver, kidney and brain mitochondria. Satav JG, et al. Mol Cell Endocrinol, 1982 Oct. PMID 6215275
  5. Isolation of the cytochrome-bc1 complex from rat-liver mitochondria. Gellerfors P, et al. Eur J Biochem, 1981 Apr. PMID 6263624

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepcidin or enterocyte iron levels may be involved in the regulation of the age-dependent expression in the duodenum.
    Title: Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquinol-cytochrome-c reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquinol-cytochrome-c reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in electron transport coupled proton transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISO
Inferred from Sequence Orthology
more info
  
involved_in response to D-galactosamine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cadmium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to cobalamin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to copper ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucagon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to mercury ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001665.2 Reference assembly

    Range
    14136..15278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_665641.1 cytochrome b (mitochondrion) [Rattus norvegicus]

    See identical proteins and their annotated locations for YP_665641.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00159
    UniProtKB/TrEMBL
    B0M1Q8, D6NSR7, D6NSR8, F2Q6S5, H2KXA0, Q5UAI7, Q8HIC4
    Conserved Domains (1) summary
    MTH00100
    Location:1 → 379
    CYTB; cytochrome b; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00159.3

Gene LinkOut

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