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atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [ Danio rerio (zebrafish) ]

Gene ID: 260440, updated on 9-Dec-2024

Summary

Official Symbol
atp2a1provided by ZNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-020905-1
See related
Ensembl:ENSDARG00000020574 AllianceGenome:ZFIN:ZDB-GENE-020905-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb279; serca; serca1; zgc:92110; wu:cegs655; wu:fb17h11; wu:fb19b10
Summary
Predicted to enable P-type calcium transporter activity. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; negative regulation of muscle contraction; and relaxation of skeletal muscle. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including digestive system; eye; mesoderm; musculature system; and pectoral fin. Used to study Brody myopathy. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See atp2a1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26145034..26154478)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26014163..26023607)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490006 Neighboring gene heat shock cognate 70-kd protein, tandem duplicate 3 Neighboring gene uncharacterized LOC103910249 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene si:ch211-11k18.4

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Markers

Clone Names

  • MGC92110

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Names
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
acc
accordion
sarcoendoplasmic reticulum calcium ATPase
NP_001007030.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007029.1NP_001007030.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1

    See identical proteins and their annotated locations for NP_001007030.1

    Status: PROVISIONAL

    Source sequence(s)
    AB178533
    UniProtKB/TrEMBL
    F6NLB7, Q5W924, Q642Z0
    Related
    ENSDARP00000135633.1, ENSDART00000162546.3
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    26145034..26154478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)