Carhsp1 calcium regulated heat stable protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Carhsp1provided by RGD
Official Full Name: calcium regulated heat stable protein 1provided by RGD
Primary source: RGD:708415
See related: EnsemblRapid:ENSRNOG00000002610 AllianceGenome:RGD:708415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crhsp24; Crhsp-24
Summary: Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule and cytosol. Predicted to be part of cytoplasmic exosome (RNase complex). Predicted to be active in cytoplasm. Orthologous to human CARHSP1 (calcium regulated heat stable protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 134.0), Lung (RPKM 105.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (7453602..7467218)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (6946036..6960556)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (7041510..7055107)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coordinate phosphorylation of four serines explains the multiple phosphorylated isoforms of CRHSP-24 present in acinar cells.
Title: Identification of calcineurin regulated phosphorylation sites on CRHSP-24.
data indicate that calcium-regulated heat-stable protein-24 is regulated by diverse and physiologically relevant signaling pathways in pancreatic acinar cells
Title: CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells.
The purification and identification of CRHSP24 in rat liver extracts, and its role as a substrate for multiple enzymes are reported.
Title: Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130567 (e-PCR)
- UniSTS:213851

RH141389 (e-PCR)
- UniSTS:223385

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P granule	ISO Inferred from Sequence Orthology more info
located_in P granule	ISS Inferred from Sequence or Structural Similarity more info
located_in P-body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium-regulated heat stable protein 1

Names: calcium-regulated heat-stable protein (24kD); calcium-regulated heat-stable protein of 24 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152790.3 → NP_690003.1 calcium-regulated heat stable protein 1

See identical proteins and their annotated locations for NP_690003.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9WU49

UniProtKB/TrEMBL

A0A8I6AMM1, A6K4L7

Related

ENSRNOP00000102913.1, ENSRNOT00000158886.1

Conserved Domains (1) summary

cd04458
Location:63 → 128

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

7453602..7467218

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245753.5 → XP_006245815.1 calcium-regulated heat stable protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZMT7, A0A8I6AMM1

Related

ENSRNOP00000003514.4, ENSRNOT00000003514.7

Conserved Domains (1) summary

cd04458
Location:83 → 148

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_039085307.2 → XP_038941235.2 calcium-regulated heat stable protein 1 isoform X3
XM_006245750.5 → XP_006245812.2 calcium-regulated heat stable protein 1 isoform X1

UniProtKB/Swiss-Prot

Q9WU49

UniProtKB/TrEMBL

A0A8I6AMM1, A6K4L7

Conserved Domains (1) summary

cd04458
Location:63 → 128

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_039085306.2 → XP_038941234.2 calcium-regulated heat stable protein 1 isoform X4