bbs-1 BBSome complex member BBS1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: bbs-1
Official Full Name: BBSome complex member BBS1
Primary source: WormBase:WBGene00000241
Locus tag: CELE_Y105E8A.5
See related: AllianceGenome:WB:WBGene00000241
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable patched binding activity and smoothened binding activity. Involved in non-motile cilium assembly. Acts upstream of or within intraciliary retrograde transport and protein localization to cilium. Located in axoneme; ciliary basal body; and neuron projection. Is expressed in intestine and nervous system. Used to study obesity. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 1. Orthologous to human BBS1 (Bardet-Biedl syndrome 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See bbs-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (14371138..14376086, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y105E8C.u (e-PCR)
- UniSTS:323837

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables smoothened binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intraciliary retrograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BBSome	IBA Inferred from Biological aspect of Ancestor more info
part_of BBSome	IEA Inferred from Electronic Annotation more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: BBSome complex member BBS1

NP_740933.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14371138..14376086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170937.3 → NP_740933.1 BBSome complex member BBS1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740933.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NEZ7

Conserved Domains (1) summary

pfam14779
Location:12 → 261

BBS1; Ciliary BBSome complex subunit 1