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dcar-1 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 259679, updated on 4-Jan-2025

Summary

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Official Symbol
dcar-1
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00007395
Locus tag
CELE_C06H5.7
See related
AllianceGenome:WB:WBGene00007395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neuropeptide receptor activity. Involved in defense response to fungus and response to wounding. Located in apical plasma membrane and non-motile cilium. Is expressed in PVQ; amphid neurons; hyp7 syncytium; and uterus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dcar-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (17910319..17917239)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Cucumopine_C domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans. Aoki R, et al. J Neurosci, 2011 Nov 16. PMID 22090488, Free PMC Article
  2. Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Zugasti O, et al. Nat Immunol, 2014 Sep. PMID 25086774, Free PMC Article
  3. Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans. Pukkila-Worley R. PLoS Pathog, 2016 Sep. PMID 27631629, Free PMC Article
  4. Breaking barriers: a GPCR triggers immunity in nematodes. Luallen RJ, et al. Nat Immunol, 2014 Sep. PMID 25137464
  5. Microbial pathogenesis and host defense in the nematode C. elegans. Cohen LB, et al. Curr Opin Microbiol, 2015 Feb. PMID 25461579, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings reveal DCAR-1 and its cognate ligand HPLA to be triggers of the epidermal innate immune response in C. elegans and highlight the ancient role of GPCRs in host defense.
    Title: Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_507511.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    17910319..17917239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075110.7 → NP_507511.2  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507511.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDI0
    Conserved Domains (2) summary
    cd14964
    Location:74 → 96
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:45 → 299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
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Gene LinkOut

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