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rbm-25 PWI domain-containing protein;RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 259655, updated on 9-Dec-2024

Summary

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Official Symbol
rbm-25
Official Full Name
PWI domain-containing protein;RRM domain-containing protein
Primary source
WormBase:WBGene00012245
Locus tag
CELE_W04D2.6
See related
AllianceGenome:WB:WBGene00012245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rbm-25 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (12498213..12503708)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Innexin;Innexin-11 Neighboring gene Ribosomal protein S11 Neighboring gene C2H2-type domain-containing protein Neighboring gene L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. Fortes P, et al. FEBS Lett, 2007 Jun 26. PMID 17560998
  2. Synaptic protein UNC-13 interacts with an F-box protein that may target it for degradation by proteasomes. Polinsky C, et al. Acta Biochim Pol, 2006. PMID 16496042
  3. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
  4. Robust regulatory architecture of pan-neuronal gene expression. Leyva-Díaz E, et al. Curr Biol, 2022 Apr 25. PMID 35259341, Free PMC Article
  5. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PWI domain-containing protein;RRM domain-containing protein
NP_001256427.1
  • Confirmed by transcript evidence
NP_506133.2
  • Confirmed by transcript evidence
NP_506134.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12498213..12503708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269498.3 → NP_001256427.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2D0
    Conserved Domains (4) summary
    PTZ00121
    Location:116 → 449
    PTZ00121; MAEBL; Provisional
    smart00311
    Location:628 → 701
    PWI; domain in splicing factors
    COG4372
    Location:300 → 452
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd12446
    Location:49 → 129
    RRM_RBM25; RNA recognition motif in eukaryotic RNA-binding protein 25 and similar proteins

  2. NM_073732.8 → NP_506133.2  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506133.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE97
    Conserved Domains (3) summary
    PTZ00121
    Location:116 → 451
    PTZ00121; MAEBL; Provisional
    smart00311
    Location:626 → 699
    PWI; domain in splicing factors
    cd12446
    Location:49 → 129
    RRM_RBM25; RNA recognition motif in eukaryotic RNA-binding protein 25 and similar proteins

  3. NM_073733.6 → NP_506134.3  PWI domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506134.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4F3
    Conserved Domains (2) summary
    PTZ00121
    Location:101 → 245
    PTZ00121; MAEBL; Provisional
    smart00311
    Location:420 → 493
    PWI; domain in splicing factors
Nucleotide Protein
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