caspb caspase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: caspbprovided by ZNC
Official Full Name: caspase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020812-1
See related: Ensembl:ENSDARG00000052039 AllianceGenome:ZFIN:ZDB-GENE-020812-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: caspy2; casp19a; zgc:109807; si:ch211-233g6.8
Summary: Enables aspartic-type peptidase activity; cysteine-type endopeptidase activity; and lipopolysaccharide binding activity. Involved in several processes, including defense response to bacterium; positive regulation of pyroptotic inflammatory response; and self proteolysis. Acts upstream of or within positive regulation of apoptotic process and pyroptotic inflammatory response. Part of NLRP1 inflammasome complex. Is expressed in several structures, including digestive system; heart; immune system; integument; and muscle. Orthologous to human CASP4 (caspase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (58050910..58064721, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (57315228..57329039, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aspartic-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in self proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NLRP1 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NLRP1 inflammasome complex	IPI Inferred from Physical Interaction more info	PubMed
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of canonical inflammasome complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caspase b

Names: caspase 19a

NP_690840.2

EC 3.4.22.58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152884.2 → NP_690840.2 caspase b

See identical proteins and their annotated locations for NP_690840.2

Status: PROVISIONAL

Source sequence(s)

BC095000

UniProtKB/Swiss-Prot

A0A0R4ILD1, Q4U0E2, Q504J1, Q9DDJ2

Related

ENSDARP00000068268.4, ENSDART00000073778.6

Conserved Domains (2) summary

cd00032
Location:163 → 401

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08321
Location:5 → 84

Pyrin_ASC-like; Pyrin Death Domain found in ASC