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pcdh10a protocadherin 10a [ Danio rerio (zebrafish) ]

Gene ID: 259186, updated on 4-Jan-2025

Summary

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Official Symbol
pcdh10aprovided by ZNC
Official Full Name
protocadherin 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020731-1
See related
Ensembl:ENSDARG00000099729 AllianceGenome:ZFIN:ZDB-GENE-020731-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pcr1; ZPCR1; pcdh10; fc56b06; wu:fc56b06; wu:fq40g12
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within melanocyte migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; nervous system; neural crest; neural tube; and optic vesicle. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See pcdh10a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12763436..12797552)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (12076617..12110750)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489977 Neighboring gene uncharacterized LOC137495458 Neighboring gene uncharacterized LOC137495459 Neighboring gene protocadherin 18a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. Amo R, et al. J Neurosci, 2010 Jan 27. PMID 20107084, Free PMC Article
  2. Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Williams JS, et al. Dev Biol, 2018 Dec 1. PMID 29604249, Free PMC Article
  3. Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Zhou X, et al. Oncotarget, 2016 Dec 13. PMID 27756875, Free PMC Article
  4. Chamber identity programs drive early functional partitioning of the heart. Mosimann C, et al. Nat Commun, 2015 Aug 26. PMID 26306682, Free PMC Article
  5. Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. Turner KJ, et al. PLoS One, 2019. PMID 30695021, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within melanocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin-10a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212571.1 → NP_997736.1  protocadherin-10a precursor

    See identical proteins and their annotated locations for NP_997736.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066445
    UniProtKB/TrEMBL
    A0A8M1PKR2, Q6NYV7
    Related
    ENSDARP00000144991.1, ENSDART00000180121.1
    Conserved Domains (3) summary
    cd11304
    Location:233 → 333
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:17 → 99
    Cadherin_2; Cadherin-like
    pfam16492
    Location:677 → 791
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    12763436..12797552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306587.4 → XP_009304862.1  protocadherin-10a isoform X1

    UniProtKB/TrEMBL
    A0A2R8QI99, A0A8M3BE35
    Related
    ENSDARP00000152743.1, ENSDART00000189465.1
    Conserved Domains (3) summary
    cd11304
    Location:233 → 333
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:17 → 99
    Cadherin_2; Cadherin-like
    pfam16492
    Location:677 → 791
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

  2. XM_009306589.4 → XP_009304864.1  protocadherin-10a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B7B9
    Conserved Domains (3) summary
    cd11304
    Location:233 → 333
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:17 → 99
    Cadherin_2; Cadherin-like
    pfam16492
    Location:677 → 791
    Cadherin_C_2; Cadherin cytoplasmic C-terminal
Nucleotide Protein Strain
Heading Accession and Version

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