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Cd3d CD3 delta subunit of T-cell receptor complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 25710, updated on 9-Dec-2024

Summary

Official Symbol
Cd3dprovided by RGD
Official Full Name
CD3 delta subunit of T-cell receptor complexprovided by RGD
Primary source
RGD:2304
See related
EnsemblRapid:ENSRNOG00000015994 AllianceGenome:RGD:2304
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and positive thymic T cell selection. Predicted to be located in plasma membrane. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 19 and severe combined immunodeficiency. Orthologous to human CD3D (CD3 delta subunit of T-cell receptor complex). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 3195.3) See more
Orthologs
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Genomic context

See Cd3d in Genome Data Viewer
Location:
8q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54184573..54190112)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45287803..45293342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49282502..49287095)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4A Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A, pseudogene 1 Neighboring gene CD3 gamma subunit of T-cell receptor complex Neighboring gene CD3 epsilon subunit of T-cell receptor complex Neighboring gene myelin protein zero-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive thymic T cell selection IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive thymic T cell selection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive thymic T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of alpha-beta T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of alpha-beta T cell receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of alpha-beta T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD3 delta chain
Names
CD3 antigen delta polypeptide
CD3 molecule delta polypeptide
CD3 molecule, delta
CD3d molecule
T-cell receptor T3 delta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013169.1NP_037301.1  T-cell surface glycoprotein CD3 delta chain precursor

    See identical proteins and their annotated locations for NP_037301.1

    Status: PROVISIONAL

    Source sequence(s)
    X53430
    UniProtKB/Swiss-Prot
    P19377
    UniProtKB/TrEMBL
    A0A8L2QB67, A6J422
    Related
    ENSRNOP00000101621.1, ENSRNOT00000127768.1
    Conserved Domains (2) summary
    pfam02189
    Location:146165
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16680
    Location:3195
    Ig_4; T-cell surface glycoprotein CD3 delta chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54184573..54190112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080903.2XP_038936831.1  T-cell surface glycoprotein CD3 delta chain isoform X1

    Conserved Domains (2) summary
    pfam02189
    Location:7392
    ITAM; Immunoreceptor tyrosine-based activation motif
    cl11960
    Location:1931
    Ig; Immunoglobulin domain