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KANK3 KN motif and ankyrin repeat domains 3 [ Homo sapiens (human) ]

Gene ID: 256949, updated on 27-Nov-2024

Summary

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Official Symbol
KANK3provided by HGNC
Official Full Name
KN motif and ankyrin repeat domains 3provided by HGNC
Primary source
HGNC:HGNC:24796
See related
Ensembl:ENSG00000186994 MIM:614611; AllianceGenome:HGNC:24796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANKRD47
Summary
Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in fat (RPKM 11.4), spleen (RPKM 8.7) and 21 other tissues See more
Orthologs
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Genomic context

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See KANK3 in Genome Data Viewer
Location:
19p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8322584..8343262, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8309103..8329720, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8387468..8408146, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8368800-8369366 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372005-8372745 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372746-8373485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8373541-8374070 Neighboring gene CD320 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8376825-8377427 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8380680-8381486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8384379-8385346 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:8385347-8386314 and GRCh37_chr19:8386315-8387282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8387283-8388248 Neighboring gene ribosomal protein S28 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8405154-8405654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8407589-8408380 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13914 Neighboring gene angiopoietin like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KANK3 mediates the p38 MAPK pathway to regulate the proliferation and invasion of lung adenocarcinoma cells. Dai Z, et al. Tissue Cell, 2023 Feb. PMID 36463587
  2. KANK family proteins in cancer. Tadijan A, et al. Int J Biochem Cell Biol, 2021 Feb. PMID 33309958
  3. A novel HIF1AN substrate KANK3 plays a tumor-suppressive role in hepatocellular carcinoma. Kim I, et al. Cell Biol Int, 2018 Mar. PMID 29047187
  4. Kank proteins: structure, functions and diseases. Kakinuma N, et al. Cell Mol Life Sci, 2009 Aug. PMID 19554261, Free PMC Article
  5. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Zhu Y, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996375

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ46061

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 3
Names
ankyrin repeat domain 47
ankyrin repeat domain-containing protein 47
kidney ankyrin repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198471.3 → NP_940873.2  KN motif and ankyrin repeat domain-containing protein 3

    See identical proteins and their annotated locations for NP_940873.2

    Status: VALIDATED

    Source sequence(s)
    BC066124
    Consensus CDS
    CCDS12199.1
    UniProtKB/Swiss-Prot
    Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2
    UniProtKB/TrEMBL
    B0I1P5
    Related
    ENSP00000328923.2, ENST00000330915.7
    Conserved Domains (5) summary
    PHA03247
    Location:59 → 181
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:617 → 763
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR03480
    Location:188 → 287
    HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
    sd00045
    Location:622 → 692
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:33 → 74
    KN_motif; KN motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    8322584..8343262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722718.5 → XP_006722781.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006722781.1

    UniProtKB/Swiss-Prot
    Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2
    UniProtKB/TrEMBL
    B0I1P5
    Conserved Domains (5) summary
    PHA03247
    Location:59 → 181
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:617 → 763
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR03480
    Location:188 → 287
    HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
    sd00045
    Location:622 → 692
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:33 → 74
    KN_motif; KN motif

  2. XM_011527884.2 → XP_011526186.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011526186.1

    UniProtKB/Swiss-Prot
    Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2
    UniProtKB/TrEMBL
    B0I1P5
    Conserved Domains (5) summary
    PHA03247
    Location:59 → 181
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:617 → 763
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR03480
    Location:188 → 287
    HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
    sd00045
    Location:622 → 692
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:33 → 74
    KN_motif; KN motif

  3. XM_017026563.3 → XP_016882052.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    B0I1P5

RNA

  1. XR_007066726.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    8309103..8329720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320456.1 → XP_054176431.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

  2. XM_054320455.1 → XP_054176430.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

  3. XM_054320454.1 → XP_054176429.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

RNA

  1. XR_008485131.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NY19.2 GenPept UniProtKB/Swiss-Prot:Q6NY19

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