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Mak male germ cell-associated kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25677, updated on 4-Jan-2025

Summary

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Official Symbol
Makprovided by RGD
Official Full Name
male germ cell-associated kinaseprovided by RGD
Primary source
RGD:3036
See related
EnsemblRapid:ENSRNOG00000015101 AllianceGenome:RGD:3036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in several processes, including cilium organization; photoreceptor cell maintenance; and protein autophosphorylation. Predicted to act upstream of or within negative regulation of non-motile cilium assembly. Predicted to be located in several cellular components, including cytoskeleton; midbody; and photoreceptor cell cilium. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 86.6) and Lung (RPKM 12.4) See more
Orthologs
human mouse all
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Genomic context

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See Mak in Genome Data Viewer
Location:
17p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23889417..23936857)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23683753..23731125)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21531651..21567742)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex protein 2-like Neighboring gene glial cells missing transcription factor 2 Neighboring gene uncharacterized LOC134482840 Neighboring gene transmembrane protein 14C Neighboring gene PAK1 interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Tucker BA, et al. Proc Natl Acad Sci U S A, 2011 Aug 23. PMID 21825139, Free PMC Article
  2. Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. Ma AH, et al. Cancer Res, 2006 Sep 1. PMID 16951154
  3. Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells. Xia L, et al. J Biol Chem, 2002 Sep 20. PMID 12084720
  4. A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Matsushime H, et al. Mol Cell Biol, 1990 May. PMID 2183027, Free PMC Article
  5. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1. Wang LY, et al. Oncogene, 2012 Jun 14. PMID 21986944, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93585

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in photoreceptor cell maintenance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within photoreceptor cell maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in photoreceptor cell maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in photoreceptor cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in photoreceptor connecting cilium IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor connecting cilium ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor inner segment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MAK
NP_037268.2
XP_038951317.1
XP_038951319.1
XP_038951321.1
XP_038951322.1
XP_038951323.1
XP_038951324.1
XP_063132181.1
XP_063132182.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013136.3 → NP_037268.2  serine/threonine-protein kinase MAK

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    G3V7Y4, P20793, Q6AYW0
    UniProtKB/TrEMBL
    A0A8I6G9U0
    Conserved Domains (1) summary
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    23889417..23936857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276111.1 → XP_063132181.1  serine/threonine-protein kinase MAK isoform X2

    UniProtKB/TrEMBL
    A0A8I6G9U0

  2. XM_063276112.1 → XP_063132182.1  serine/threonine-protein kinase MAK isoform X4

    UniProtKB/TrEMBL
    A0A8I6AB71

  3. XM_039095389.2 → XP_038951317.1  serine/threonine-protein kinase MAK isoform X1

    UniProtKB/Swiss-Prot
    G3V7Y4, P20793, Q6AYW0
    UniProtKB/TrEMBL
    A0A8I6G9U0
    Related
    ENSRNOP00000020672.4, ENSRNOT00000020672.9
    Conserved Domains (1) summary
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  4. XM_039095395.2 → XP_038951323.1  serine/threonine-protein kinase MAK isoform X4

    UniProtKB/TrEMBL
    A0A8I6AB71
    Related
    ENSRNOP00000079083.1, ENSRNOT00000107200.2
    Conserved Domains (1) summary
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  5. XM_039095396.1 → XP_038951324.1  serine/threonine-protein kinase MAK isoform X5

    UniProtKB/TrEMBL
    A0A8I6G9U0
    Related
    ENSRNOP00000084056.2, ENSRNOT00000105813.2
    Conserved Domains (1) summary
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  6. XM_039095393.1 → XP_038951321.1  serine/threonine-protein kinase MAK isoform X2

    UniProtKB/TrEMBL
    A0A8I6G9U0
    Conserved Domains (1) summary
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  7. XM_039095391.2 → XP_038951319.1  serine/threonine-protein kinase MAK isoform X1

    UniProtKB/Swiss-Prot
    G3V7Y4, P20793, Q6AYW0
    UniProtKB/TrEMBL
    A0A8I6G9U0
    Conserved Domains (1) summary
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  8. XM_039095394.2 → XP_038951322.1  serine/threonine-protein kinase MAK isoform X3

    UniProtKB/TrEMBL
    A0A8I6G9U0
    Conserved Domains (1) summary
    cd07830
    Location:1 → 250
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20793.2 GenPept UniProtKB/Swiss-Prot:P20793

Gene LinkOut

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