Bmp3 bone morphogenetic protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmp3provided by RGD
Official Full Name: bone morphogenetic protein 3provided by RGD
Primary source: RGD:2212
See related: EnsemblRapid:ENSRNOG00000002381 AllianceGenome:RGD:2212
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PBMP3
Summary: Enables growth factor activity. Predicted to be involved in cartilage development; osteoblast differentiation; and signal transduction. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Orthologous to human BMP3 (bone morphogenetic protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 36.3), Lung (RPKM 34.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (11012564..11041282, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (10712489..10737153, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (12362912..12387572, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.
Title: Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.
Data indicate that bone morphogenetic protein-3 (BMP3) is widely expressed throughout the adult central nervous system, and its abundant expression in the adult brain strongly supports the idea that BMP3 plays important roles in the adult brain.
Title: BMP3 expression in the adult rat CNS.
Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
Title: Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
Bmp3 expression in a special layer of typical articular cartilage may be regulated by mechanical stress stimulation. We also found that Bmp3 was expressed in the periosteal layers of the bone segments near the fracture site during fracture healing.
Title: Bone morphogenetic protein 3 expression pattern in rat condylar cartilage, femoral cartilage and mandibular fracture callus.
BMP3 is expressed in rat cranial sutures in a temporal pattern suggesting involvement in cranial suture patency and fusion.
Title: Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures.

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General gene information

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Markers

RH138863 (e-PCR)
- UniSTS:220950

D14Wox27 (e-PCR)
- UniSTS:518517

RH94474 (e-PCR)
- UniSTS:119722

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP receptor binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein 3

Names: BMP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017105.1 → NP_058801.1 bone morphogenetic protein 3 precursor

See identical proteins and their annotated locations for NP_058801.1

Status: PROVISIONAL

Source sequence(s)

D63860

UniProtKB/Swiss-Prot

P49002

UniProtKB/TrEMBL

A0A8I6A2A8, A6K643

Related

ENSRNOP00000084580.1, ENSRNOT00000104172.2

Conserved Domains (2) summary

pfam00019
Location:364 → 467

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:46 → 203

TGFb_propeptide; TGF-beta propeptide