U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25547, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
St8sia3provided by RGD
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by RGD
Primary source
RGD:3680
See related
EnsemblRapid:ENSRNOG00000018305 AllianceGenome:RGD:3680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat8c
Summary
Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and identical protein binding activity. Predicted to be involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and sialylation. Predicted to be located in Golgi membrane. Orthologous to human ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 122.4), Liver (RPKM 72.2) and 1 other tissue See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See St8sia3 in Genome Data Viewer
Location:
18q12.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (60024555..60031050)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57754349..57760839)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59748766..59755257)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene peroxiredoxin 1, pseudogene 4 Neighboring gene uncharacterized LOC102553013 Neighboring gene RGD1562699 Neighboring gene one cut homeobox 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Volkers G, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26192331
  2. Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III). Lee YC, et al. Arch Biochem Biophys, 1998 Dec 1. PMID 9826427
  3. Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase. Zeng G, et al. Gene, 1997 Mar 10. PMID 9073076
  4. Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. Yoshida Y, et al. J Biol Chem, 1995 Jun 16. PMID 7782326
  5. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. Angata K, et al. J Biol Chem, 2000 Jun 16. PMID 10766765

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Names
GT3-synthase
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 3
Sialyltransferase 8 (GT3 alpha 2,8-sialyltransferase) C
Sialyltransferase 8 (GT3 alpha 28-sialyltransferase) C
sialyltransferase 8 C
NP_037161.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013029.2 → NP_037161.2  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6IXN4, G3V8D0, P97877
    Related
    ENSRNOP00000024752.2, ENSRNOT00000024752.6
    Conserved Domains (1) summary
    pfam00777
    Location:113 → 376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    60024555..60031050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools