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Prkg2 protein kinase cGMP-dependent 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25523, updated on 27-Nov-2024

Summary

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Official Symbol
Prkg2provided by RGD
Official Full Name
protein kinase cGMP-dependent 2provided by RGD
Primary source
RGD:3401
See related
EnsemblRapid:ENSRNOG00000002361 AllianceGenome:RGD:3401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
cGKII; GDPKII
Summary
Enables cGMP-dependent protein kinase activity and identical protein binding activity. Involved in several processes, including negative regulation of chloride transport; peptidyl-serine autophosphorylation; and positive regulation of chondrocyte differentiation. Located in nuclear membrane. Biomarker of withdrawal disorder. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-4 and spondylometaphyseal dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 73.7), Brain (RPKM 40.7) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prkg2 in Genome Data Viewer
Location:
14p22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (10864020..10972617)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (10559882..10668479)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (12217121..12313616)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RasGEF domain family, member 1B Neighboring gene uncharacterized LOC120096570 Neighboring gene PRELI domain containing 1, pseudogene 4 Neighboring gene uncharacterized LOC134481716 Neighboring gene bone morphogenetic protein 3 Neighboring gene cilia and flagella associated protein 299 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The regulation of synaptic vesicle recycling by cGMP-dependent protein kinase type II in cerebellar granule cells under strong and sustained stimulation. Collado-Alsina A, et al. J Neurosci, 2014 Jun 25. PMID 24966379, Free PMC Article
  2. Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. Tsuchida A, et al. Comp Med, 2008 Dec. PMID 19149413, Free PMC Article
  3. cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene. Gambaryan S, et al. J Biol Chem, 2003 Aug 8. PMID 12775716
  4. Protein kinase G type II is required for night-to-day progression of the mammalian circadian clock. Tischkau SA, et al. Neuron, 2004 Aug 19. PMID 15312652
  5. STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Golin-Bisello F, et al. Am J Physiol Cell Physiol, 2005 Sep. PMID 15872007

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a low affinity for cGMP, did not.
    Title: Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells.
  2. We conclude that cGKII controls the homeostatic balance of vesicle exocytosis and endocytosis in synaptic boutons of rat cerebellar granule cells.
    Title: The regulation of synaptic vesicle recycling by cGMP-dependent protein kinase type II in cerebellar granule cells under strong and sustained stimulation.
  3. Which in turn activates cGKII and induces the phosphorylation of GluA1.
    Title: The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells.
  4. Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
    Title: Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
  5. confirmed mutation in Prkg2 is a valuable model for studying dwarfism and longitudinal growth traits
    Title: Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2.
  6. a subset of phosphorylation sites is modulated, in a cGMP-PKG-specific manner, in intact HEK cells heterologously expressing Cav1.2 alpha(1c) and beta(2a) subunits
    Title: Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits.
  7. PKG II activity in zona glomerulosa cells is important for maintaining basal aldosterone production
    Title: cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.
  8. results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form
    Title: Autophosphorylation of cGMP-dependent protein kinase type II.
  9. Protein kinase G regulation of interleukin 6 promoter signaling pathway largely prevented fluid shear stress-induced increases of IL-6 mRNA in osteosarcoma cells.
    Title: Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts.
  10. eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin on growth and proliferation of hepatoma cells
    Title: eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cGMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular hypotonic response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell volume ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cGMP-dependent protein kinase 2
Names
CGK 2
cGK2
cGMP dependent protein kinase type II
cGMP-dependent protein kinase II
protein kinase, cGMP- dependent, type 2
protein kinase, cGMP-dependent, type II
type II cGMP-dependent protein kinase
NP_037144.1
XP_038947566.1
XP_063128946.1
XP_063128947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013012.2 → NP_037144.1  cGMP-dependent protein kinase 2

    See identical proteins and their annotated locations for NP_037144.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q64595
    Related
    ENSRNOP00000003237.2, ENSRNOT00000003237.6
    Conserved Domains (4) summary
    PTZ00263
    Location:417 → 752
    PTZ00263; protein kinase A catalytic subunit; Provisional
    COG0664
    Location:162 → 285
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:286 → 401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:459 → 718
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    10864020..10972617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091638.2 → XP_038947566.1  cGMP-dependent protein kinase 2 isoform X1

    Conserved Domains (2) summary
    cd00038
    Location:286 → 401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:439 → 689
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

  2. XM_063272876.1 → XP_063128946.1  cGMP-dependent protein kinase 2 isoform X2

  3. XM_063272877.1 → XP_063128947.1  cGMP-dependent protein kinase 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64595.1 GenPept UniProtKB/Swiss-Prot:Q64595

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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