Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcne1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily E regulatory subunit 1provided by RGD
Primary source: RGD:2956
See related: EnsemblRapid:ENSRNOG00000001984 AllianceGenome:RGD:2956
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Isk
Summary: Enables delayed rectifier potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to acidic pH; negative regulation of protein targeting to membrane; and regulation of cation channel activity. Located in Z disc and apical plasma membrane. Part of voltage-gated potassium channel complex. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Testes (RPKM 15.4), Kidney (RPKM 10.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (45066875..45080024, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (31580951..31594116, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (32498260..32511202, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
Title: Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress.
Title: Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the I(Ks) Amplitude in Check Until When Larger I(Ks) Is Needed.
Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells.
Title: BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
KCNE1 and KCNE2 suppress currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels
Title: KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition.
currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels are all strongly suppressed by the single transmembrane domain ancillary (beta) subunits KCNE1 and KCNE2
Title: KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels.
both the voltage-dependence and kinetics of gating were found to depend on the relative densities of KCNQ1 and KCNE1, suggesting the heart rhythm may be regulated by the relative expression of the auxiliary subunit
Title: Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.
Rat MinK and MiRP1 reduced Kv2.1 current density three- and twofold, respectively; slowed Kv2.1 activation (at +60 mV) two- and threefold, respectively; and slowed Kv2.1 deactivation less than twofold.
Title: Regulation of the Kv2.1 potassium channel by MinK and MiRP1.
Suggest that KCNE1 stabilizes KCNQ1 S4 segment in the resting state and slows the rate of transition to the active state, while KCNE3 stabilizes the S4 segment in the active state.
Title: KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel.
Expression of KCNQ1 and KCNE1 associated with early stages of spermatogenesis and with presence of undifferentiated healthy or neoplastic germ cells. KCNQ1/KCNE1 may be involved in K+ transport, probably during germ-cell development.
Title: KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables telethonin binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
NOT enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epithelial cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in vestibular nucleus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily E member 1

Names: IKs producing slow voltage-gated potassium channel subunit beta Mink; delayed rectifier potassium channel subunit IsK; minimal potassium channel; mink; potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012973.1 → NP_037105.1 potassium voltage-gated channel subfamily E member 1

See identical proteins and their annotated locations for NP_037105.1

Status: PROVISIONAL

Source sequence(s)

M22412

UniProtKB/Swiss-Prot

P15383

UniProtKB/TrEMBL

A6JLJ7

Conserved Domains (1) summary

pfam02060
Location:2 → 127

ISK_Channel; Slow voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

45066875..45080024 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597886.3 → XP_017453375.1 potassium voltage-gated channel subfamily E member 1 isoform X1

UniProtKB/Swiss-Prot

P15383

UniProtKB/TrEMBL

A6JLJ7

Related

ENSRNOP00000106444.1, ENSRNOT00000146457.1

Conserved Domains (1) summary

pfam02060
Location:2 → 127

ISK_Channel; Slow voltage-gated potassium channel
XM_006248035.4 → XP_006248097.1 potassium voltage-gated channel subfamily E member 1 isoform X1

See identical proteins and their annotated locations for XP_006248097.1

UniProtKB/Swiss-Prot

P15383

UniProtKB/TrEMBL

A6JLJ7

Related

ENSRNOP00000108944.1, ENSRNOT00000168964.1

Conserved Domains (1) summary

pfam02060
Location:2 → 127

ISK_Channel; Slow voltage-gated potassium channel
XM_017597887.3 → XP_017453376.1 potassium voltage-gated channel subfamily E member 1 isoform X1

UniProtKB/Swiss-Prot

P15383

UniProtKB/TrEMBL

A6JLJ7

Conserved Domains (1) summary

pfam02060
Location:2 → 127

ISK_Channel; Slow voltage-gated potassium channel
XM_006248034.5 → XP_006248096.1 potassium voltage-gated channel subfamily E member 1 isoform X1

See identical proteins and their annotated locations for XP_006248096.1

UniProtKB/Swiss-Prot

P15383

UniProtKB/TrEMBL

A6JLJ7

Related

ENSRNOP00000111040.1, ENSRNOT00000139012.1

Conserved Domains (1) summary

pfam02060
Location:2 → 127

ISK_Channel; Slow voltage-gated potassium channel