Gfra1 GDNF family receptor alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gfra1provided by RGD
Full Name: GDNF family receptor alpha 1provided by RGD
Primary source: RGD:2681
See related: EnsemblRapid:ENSRNOG00000017438 AllianceGenome:RGD:2681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glial cell-derived neurotrophic factor receptor activity; integrin binding activity; and neurotrophin receptor activity. Involved in several processes, including glial cell-derived neurotrophic factor receptor signaling pathway; male gonad development; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Part of plasma membrane protein complex and receptor complex. Used to study Parkinsonism. Biomarker of Parkinsonism; brain ischemia; and sciatic neuropathy. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 49.8), Kidney (RPKM 48.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (267325297..267557037, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (257315682..257552004, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (279203046..279572789, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression of RET and GDNF family receptor, GFR-alpha1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
Title: Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
The findings demonstrate that elevated GDNF levels can reduce the retinal injury, whereby down-regulated miR-216a aggravates the YAG laser-induced retinal injury by targeting the GDNF level through the GDNF/GFRa1/RET signaling pathway.
Title: Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury via the GDNF-mediated GDNF/GFRα1/RET signalling pathway.
Exercise-Mediated Increase in Nigral gfra1 in aging rats.
Title: Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats.
these studies reveal a diverse range of potential targets by which artemin could influence bladder function, nerve regeneration, and pain.
Title: Characterization of axons expressing the artemin receptor in the female rat urinary bladder: a comparison with other major neuronal populations.
Data suggest that a dietary factor (here, docosahexaenoic acid-DHA) can up-regulate the expression of Gfra1 in hippocampal neurons of the natural aged female rat; DHA improves oxidative parameters and activates the Gdnf/Gfra1-MAPK pathway.
Title: Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat.
expression of soluble GFRalpha1 in substantia nigra may be a key component in locomotor activity regulation through its influence over TH regulation and dopamine biosynthesis.
Title: Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity.
Expression levels of GDNF and GFRalpha1 proteins increase gradually over time in experimental diabetic retinopathy under high glucose and exogenous GDNF-treated conditions.
Title: Expression of glial cell line-derived neurotrophic factor and its receptors in cultured retinal Müller cells under high glucose circumstance.
Post-synaptic striatal glial cell line-derived neurotrophic factor receptor-alpha1 expression effects the biology of dopamine neurons in vivo.
Title: Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra.
we speculate that (i) GFR alpha-1 receptor expression may regulate nigral dopamine bioavailability in vivo
Title: GFR α-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways.
these unanticipated results indicate that GFRalpha1b is involved in glioma migration through glial cell line-derived neurotrophic factor -GFRalpha1b-Neural Cell Adhesion Molecule signaling complex and modulation of RhoA expression
Title: A specific isoform of glial cell line-derived neurotrophic factor family receptor alpha 1 regulates RhoA expression and glioma cell migration.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gfra1 (e-PCR), detects polymorphism
- UniSTS:507440

Gfra1 (e-PCR), detects polymorphism
- UniSTS:143198

RH132446 (e-PCR)
- UniSTS:215729

AW529053 (e-PCR)
- UniSTS:247242

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glial cell-derived neurotrophic factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glial cell-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables glial cell-derived neurotrophic factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurotrophin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of plasma membrane protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GDNF family receptor alpha-1

Names: GDNF family receptor alpha-1-like; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR-alpha; GDNFR-alpha-1; GFR-alpha-1; Glial cell line-derived neurotrophic factor receptor alpha; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; glial cell line derived neurotrophic factor family receptor alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012959.2 → NP_037091.1 GDNF family receptor alpha-1 precursor

See identical proteins and their annotated locations for NP_037091.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q62997

UniProtKB/TrEMBL

A0A0A0MXY7, A6JI59

Conserved Domains (2) summary

smart00907
Location:154 → 233

GDNF; GDNF/GAS1 domain

pfam02351
Location:243 → 337

GDNF; GDNF/GAS1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

267325297..267557037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101768.2 → XP_038957696.1 GDNF family receptor alpha-1 isoform X1

UniProtKB/Swiss-Prot

Q62997

UniProtKB/TrEMBL

A0A0A0MXY7, A6JI59

Conserved Domains (2) summary

smart00907
Location:154 → 233

GDNF; GDNF/GAS1 domain

pfam02351
Location:243 → 337

GDNF; GDNF/GAS1 domain
XM_063281844.1 → XP_063137914.1 GDNF family receptor alpha-1 isoform X2

UniProtKB/TrEMBL

A6JI55, A6JI56, O35748
XM_063281839.1 → XP_063137909.1 GDNF family receptor alpha-1 isoform X2

UniProtKB/TrEMBL

A6JI55, A6JI56, O35748

Related

ENSRNOP00000023667.6, ENSRNOT00000023667.9
XM_039101762.2 → XP_038957690.1 GDNF family receptor alpha-1 isoform X1

UniProtKB/Swiss-Prot

Q62997

UniProtKB/TrEMBL

A0A0A0MXY7, A6JI59

Related

ENSRNOP00000091515.2, ENSRNOT00000104357.2

Conserved Domains (2) summary

smart00907
Location:154 → 233

GDNF; GDNF/GAS1 domain

pfam02351
Location:243 → 337

GDNF; GDNF/GAS1 domain
XM_008760514.4 → XP_008758736.1 GDNF family receptor alpha-1 isoform X2

See identical proteins and their annotated locations for XP_008758736.1

UniProtKB/TrEMBL

A0A0A0MXY7, A6JI55, A6JI56, O35748

Conserved Domains (2) summary

smart00907
Location:149 → 228

GDNF; GDNF/GAS1 domain

pfam02351
Location:238 → 332

GDNF; GDNF/GAS1 domain
XM_039101759.2 → XP_038957687.1 GDNF family receptor alpha-1 isoform X1

UniProtKB/Swiss-Prot

Q62997

UniProtKB/TrEMBL

A0A0A0MXY7, A6JI59

Conserved Domains (2) summary

smart00907
Location:154 → 233

GDNF; GDNF/GAS1 domain

pfam02351
Location:243 → 337

GDNF; GDNF/GAS1 domain
XM_008760512.4 → XP_008758734.1 GDNF family receptor alpha-1 isoform X1

See identical proteins and their annotated locations for XP_008758734.1

UniProtKB/Swiss-Prot

Q62997

UniProtKB/TrEMBL

A0A0A0MXY7, A6JI59

Conserved Domains (2) summary

smart00907
Location:154 → 233

GDNF; GDNF/GAS1 domain

pfam02351
Location:243 → 337

GDNF; GDNF/GAS1 domain