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dss1 proteasome receptor/ubiquitin ligase adaptor Dss1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543058, updated on 3-Nov-2024

Summary

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Official Symbol
dss1
Official Full Name
proteasome receptor/ubiquitin ligase adaptor Dss1
Primary source
PomBase:SPAC3G6.02
Locus tag
SPOM_SPAC3G6.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rpn15; sem1
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Genomic context

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See dss1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5383067..5383811)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene CHD family chromatin remodeller Hrp3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Maf-like protein Ifs1 Neighboring gene RNA-binding protein Rnp24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dss1 associating with the proteasome functions in selective nuclear mRNA export in yeast. Mannen T, et al. Biochem Biophys Res Commun, 2008 Jan 25. PMID 18023413
  2. Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro. Jacobsen NL, et al. Protein Sci, 2023 Sep. PMID 37463013, Free PMC Article
  3. Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast. Thakurta AG, et al. EMBO J, 2005 Jul 20. PMID 15990877, Free PMC Article
  4. Dss1 is a 26S proteasome ubiquitin receptor. Paraskevopoulos K, et al. Mol Cell, 2014 Nov 6. PMID 25306921, Free PMC Article
  5. A context-dependent and disordered ubiquitin-binding motif. Dreier JE, et al. Cell Mol Life Sci, 2022 Aug 16. PMID 35974206, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro.
    Title: Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro.
  2. Dss1 forms a transiently populated C-terminal helix that dynamically interacts with and shields a central binding region.
    Title: Expanded Interactome of the Intrinsically Disordered Protein Dss1.
  3. Dss1 is disordered and binds ubiquitin by binding sites characterized by acidic and hydrophobic residues.
    Title: Dss1 is a 26S proteasome ubiquitin receptor.
  4. findings show that DSS1 has an evolutionarily conserved role as a regulator of proteasome function
    Title: Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
proteasome receptor/ubiquitin ligase adaptor Dss1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5383067..5383811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020399.3 → NP_594968.1  proteasome receptor/ubiquitin ligase adaptor Dss1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594968.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14140
    Conserved Domains (1) summary
    cd13768
    Location:7 → 66
    DSS1_Sem1; proteasome complex subunit DSS1/Sem1
Nucleotide Protein
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