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Dio1 iodothyronine deiodinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25430, updated on 27-Nov-2024

Summary

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Official Symbol
Dio1provided by RGD
Official Full Name
iodothyronine deiodinase 1provided by RGD
Primary source
RGD:2504
See related
EnsemblRapid:ENSRNOG00000061237 AllianceGenome:RGD:2504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
5DI; ITDI1; TXDI1
Summary
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
Expression
Biased expression in Kidney (RPKM 1336.0) and Liver (RPKM 709.8) See more
Orthologs
human mouse all
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Genomic context

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See Dio1 in Genome Data Viewer
Location:
5q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127303089..127319784, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122074285..122090983, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126894837..126911532, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene intraflagellar transport 25 Neighboring gene uncharacterized LOC134486960 Neighboring gene Yip1 domain family, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats. Liu Y, et al. Biomed Res Int, 2021. PMID 34195279, Free PMC Article
  2. Identification of essential histidine residues in rat type I iodothyronine deiodinase. Berry MJ. J Biol Chem, 1992 Sep 5. PMID 1517238
  3. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Berry MJ, et al. Nature, 1991 Jan 31. PMID 1825132
  4. Mammary gland carcinoma-related increase of type I iodothyronine 5'-deiodinase activity in Sprague-Dawley rats. Macejová D, et al. Gen Physiol Biophys, 2001 Sep. PMID 11765219
  5. Regulatory role of the 3' untranslated region (3'UTR) of rat 5' deiodinase (D1). effects on messenger RNA translation and stability. Arroyo-Helguera O, et al. Endocrine, 2005 Aug. PMID 16230777

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study.
    Title: Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study.
  2. Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.
    Title: Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.
  3. TGF-beta1 mediates cell proliferation and development of hepatocarcinogenesis by downregulating deiodinase 1 expression.", trans "La desregulacion de la deiodinasa 1, mediada por TGF-beta1, impulsa la proliferacion celular y el desarrollo de hepatocarcinogenesis.
    Title: TGF-β1 mediates cell proliferation and development of hepatocarcinogenesis by downregulating deiodinase 1 expression.
  4. estrogen deficiency impairs the induction of thyroid hormone activating enzyme D1 in the pituitary, and GH release by acute exercise. Also, acute D1 activation is essential for exercise-induced GH response
    Title: Thyroid hormone and estrogen regulate exercise-induced growth hormone release.
  5. Response of pituitary Dio1 and brown adipose tissue Dio2 is blunted in ovariectomized rats.
    Title: Blunted response of pituitary type 1 and brown adipose tissue type 2 deiodinases to swimming training in ovariectomized rats.
  6. The effects of androgen deprivation on thyroid homeostasis, reflected in DioI and DioII expression, are reported.
    Title: Orchidectomy of middle-aged rats decreases liver deiodinase 1 and pituitary deiodinase 2 activity.
  7. Type 1 and type 2 deiodinase may have distinct functions in white adipose tissue, regulating lipogenesis and lipolysis.
    Title: Presence and regulation of D1 and D2 deiodinases in rat white adipose tissue.
  8. The study provided first evidence on the reduction of liver RAR concentrations and 5'-DI activity in response to long-term voluntary wheel running.
    Title: Changes in retinoic acid receptor status, 5'-deiodinase activity and neuroendocrine response to voluntary wheel running.
  9. The results demonstrate that decreased liver D1 and BAT D2 might be involved in the decreased T(4)-to-T(3) conversion detected after an exercise session on the treadmill.
    Title: The effect of acute exercise session on thyroid hormone economy in rats.
  10. Epididymis expresses the highest 5'-deiodinase activity in the male reproductive system.
    Title: Epididymis expresses the highest 5'-deiodinase activity in the male reproductive system: kinetic characterization, distribution, and hormonal regulation.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93462

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables selenium binding ISO
Inferred from Sequence Orthology
more info
  
enables thyroxine 5'-deiodinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroxine 5'-deiodinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thyroxine 5'-deiodinase activity IEA
Inferred from Electronic Annotation
more info
  
enables thyroxine 5'-deiodinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in generation of precursor metabolites and energy NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type I iodothyronine deiodinase
Names
DIOI
deiodinase, iodothyronine, type I
thyroxine deiodinase, type I
type 1 DI
type-I 5'-deiodinase
NP_001311139.1
NP_067685.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324210.1 → NP_001311139.1  type I iodothyronine deiodinase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which causes a frameshift compared to variant 1. The resulting isoform (2) is shorter, with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC083557, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P24389

  2. NM_021653.4 → NP_067685.5  type I iodothyronine deiodinase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC083557, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P24389
    UniProtKB/TrEMBL
    A0A0G2JXM4
    Related
    ENSRNOP00000070330.2, ENSRNOT00000091521.3
    Conserved Domains (1) summary
    cl00388
    Location:8 → 247
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    127303089..127319784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24389.2 GenPept UniProtKB/Swiss-Prot:P24389

Gene LinkOut

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Chemical Information
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Research Materials
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