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sin1 MAP kinase-interacting protein Sin1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542972, updated on 18-Sep-2024

Summary

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Official Symbol
sin1
Official Full Name
MAP kinase-interacting protein Sin1
Primary source
PomBase:SPAPYUG7.02c
Locus tag
SPOM_SPAPYUG7.02C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sin1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (4746022..4748427, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 3-kinase Pik3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD repeat-containing protein Atg1803 Neighboring gene ncRNA Neighboring gene transcription factor TFIIE subunit Tfa1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene septin ring organizing protein Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase II complex TFIIS subunit Rpb9 Neighboring gene delta-1-pyrroline-5-carboxylate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2. Du W, et al. Open Biol, 2016 Mar. PMID 26935949, Free PMC Article
  2. Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast. Morigasaki S, et al. J Cell Sci, 2019 Oct 10. PMID 31477575
  3. Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway. Wilkinson MG, et al. EMBO J, 1999 Aug 2. PMID 10428959, Free PMC Article
  4. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Hatano T, et al. Cell Cycle, 2015. PMID 25590601, Free PMC Article
  5. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Ikeda K, et al. Cell Cycle, 2008 Feb 1. PMID 18235227, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables enzyme-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAP kinase-interacting protein Sin1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4746022..4748427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020130.3 → NP_594703.1  MAP kinase-interacting protein Sin1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594703.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P7Y9, Q9Y7F5
    Conserved Domains (3) summary
    pfam05422
    Location:41 → 206
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:255 → 392
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    pfam16979
    Location:557 → 658
    SIN1_PH; SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
Nucleotide Protein
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