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rad54 DNA repair protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542749, updated on 14-Nov-2024

Summary

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Official Symbol
rad54
Official Full Name
DNA repair protein
Primary source
PomBase:SPAC15A10.03c
Locus tag
SPOM_SPAC15A10.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rhp54
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Genomic context

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See rad54 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3680360..3683265, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ABC family Fe transporter Atm1 Neighboring gene SAGA complex/transcription factor TFIID complex subunit A Taf12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-1 alpha-binding zinc finger protein Zpr1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast. Trickey M, et al. Mol Cell Biol, 2008 Jun. PMID 18426916, Free PMC Article
  2. Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation. Onaka AT, et al. Nucleic Acids Res, 2016 Dec 15. PMID 27697832, Free PMC Article
  3. The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes. Maftahi M, et al. Nucleic Acids Res, 2002 Nov 1. PMID 12409469, Free PMC Article
  4. Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity. Muris DF, et al. J Cell Sci, 1996 Jan. PMID 8834792
  5. A new recombinational DNA repair gene from Schizosaccharomyces pombe with homology to Escherichia coli RecA. Khasanov FK, et al. Genetics, 1999 Aug. PMID 10430583, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rad51 and Rad54 are required for gene silencing in centromeres, suggesting that HR also plays a role in the structure and function of centromeres.
    Title: Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation.
  2. during meiosis, expression of nondegradable Rhp54 inhibits interhomolog recombination and stimulates sister chromatid recombination
    Title: The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast.
  3. rad54 and the RAD52 orthologs rad22A and rad22B are epistatic for the repair of double-strand breaks in DNA.
    Title: Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISM
Inferred from Sequence Model
more info
  
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on acid anhydrides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gene conversion at mating-type locus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitotic spindle HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA repair protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3680360..3683265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019713.3 → NP_594290.1  DNA repair protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594290.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13723, P41410
    Conserved Domains (4) summary
    cd00046
    Location:288 → 441
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:267 → 575
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:609 → 725
    Helicase_C; Helicase conserved C-terminal domain
    pfam08658
    Location:25 → 246
    Rad54_N; Rad54 N terminal
Nucleotide Protein
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