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cut7 kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542732, updated on 30-Oct-2024

Summary

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Official Symbol
cut7
Official Full Name
kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7
Primary source
PomBase:SPAC25G10.07c
Locus tag
SPOM_SPAC25G10.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cut7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4306511..4310337, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ATP phosphoribosyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS28 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation initiation factor eIF3b (p84) Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase. Gergely ZR, et al. J Cell Sci, 2023 Mar 1. PMID 36655493, Free PMC Article
  2. Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Hagan I, et al. Nature, 1992 Mar 5. PMID 1538784
  3. Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene. Hagan I, et al. Nature, 1990 Oct 11. PMID 2145514
  4. Bidirectional motility of the fission yeast kinesin-5, Cut7. Edamatsu M. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24589736
  5. Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7. Edamatsu M. Genet Mol Res, 2016 Feb 11. PMID 26909973

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.
    Title: Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.
  2. The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase.
    Title: The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase.
  3. Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe.
    Title: Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe.
  4. Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
    Title: Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
  5. treatment with a microtubule-destabilizing drug not only suppresses cut7 temperature sensitivity but also rescues the lethality resulting from the deletion of cut7, though a single klp2 deletion per se cannot compensate for the loss of Cut7.
    Title: Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe.
  6. although deletion of either pkl1 or klp2 rescues temperature-sensitive cut7 mutants, deletion of only pkl1 can bypass the lethality caused by cut7 deletion
    Title: Two spatially distinct kinesin-14 proteins, Pkl1 and Klp2, generate collaborative inward forces against kinesin-5 Cut7 in S. pombe.
  7. The study shows that the stepping direction of Cut7, a yeast kinesin-5 motor, depends on the level of motor crowding on the microtubule, and that crowding of Cut7 by non-Cut7 proteins also can drive reversal. Thus, crowding by either dynein microtubule binding domain or Klp2, a kinesin-14, converts Cut7 from net minus end-directed to net plus end-directed stepping.
    Title: Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.
  8. Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7, have been reported.
    Title: Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7.
  9. In in vitro motility assays, full-length Cut7 moved toward minus-end of microtubules, but the N-terminal half of Cut7 moved toward the opposite direction.
    Title: Bidirectional motility of the fission yeast kinesin-5, Cut7.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables minus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in initial mitotic spindle pole body separation EXP
Inferred from Experiment
more info
 PubMed 
involved_in initial mitotic spindle pole body separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule plus-end directed mitotic chromosome migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle elongation (spindle phase three) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle formation (spindle phase one) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle midzone assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
part_of microtubule associated complex IC
Inferred by Curator
more info
  
is_active_in microtubule cytoskeleton HDA PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in polar microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4306511..4310337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019956.3 → NP_594527.1  kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594527.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P24339
    Conserved Domains (3) summary
    smart00129
    Location:72 → 428
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:398 → 966
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01364
    Location:70 → 429
    KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
Nucleotide Protein
Heading Accession and Version

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