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rhp6 ubiquitin-conjugating enzyme E2 2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542622, updated on 18-Sep-2024

Summary

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Official Symbol
rhp6
Official Full Name
ubiquitin-conjugating enzyme E2 2
Primary source
PomBase:SPAC18B11.07c
Locus tag
SPOM_SPAC18B11.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rad6; sng1; ubc2
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Genomic context

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See rhp6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (305606..306762)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein pat10 Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Lcp5 Neighboring gene dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase PIGV

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Tanny JC, et al. Genes Dev, 2007 Apr 1. PMID 17374714, Free PMC Article
  2. The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity. Dul BE, et al. J Biol Chem, 2007 Jun 22. PMID 17456468
  3. Bin1 homolog hob1 supports a Rad6-Set1 pathway of transcriptional repression in fission yeast. Ramalingam A, et al. Cell Cycle, 2007 Jul 1. PMID 17611416
  4. Caffeine-mediated override of checkpoint controls. A requirement for rhp6 (Schizosaccharomyces pombe). Rowley R, et al. Genetics, 1999 May. PMID 10224243, Free PMC Article
  5. HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast. Zofall M, et al. J Biol Chem, 2007 May 11. PMID 17363370

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Rhp6/Ubc2 and ligating enzymes Ubr1 are responsible for nuclear enrichment of proteasome through the function of Cut8, a nuclear envelope protein.
    Title: Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    305606..306762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018276.3 → NP_592876.1  ubiquitin-conjugating enzyme E2 2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592876.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P23566
    Conserved Domains (2) summary
    COG5078
    Location:1 → 150
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8 → 145
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
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