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rad1 checkpoint clamp complex protein Rad1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542558, updated on 18-Sep-2024

Summary

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Official Symbol
rad1
Official Full Name
checkpoint clamp complex protein Rad1
Primary source
PomBase:SPAC1952.07
Locus tag
SPOM_SPAC1952.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rad19
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Genomic context

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See rad1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (4978578..4980303)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene SAGA complex histone acetyltransferase catalytic subunit Gcn5 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene acetyl-CoA hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Checkpoint controls in Schizosaccharomyces pombe: rad1. Rowley R, et al. EMBO J, 1992 Apr. PMID 1563349, Free PMC Article
  2. The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+). Jansson K, et al. Mutat Res, 2008 Sep 26. PMID 18675827
  3. A role for Myh1 in DNA repair after treatment with strand-breaking and crosslinking chemotherapeutic agents. Jansson K, et al. Environ Mol Mutagen, 2013 Jun. PMID 23677513
  4. The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast. Wan S, et al. Yeast, 1999 Jul. PMID 10407262
  5. Functions of fission yeast orp2 in DNA replication and checkpoint control. Kiely J, et al. Genetics, 2000 Feb. PMID 10655214, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. myh1 rad1 double mutants exhibit morphological defects in the absence of DNA damaging agents.
    Title: The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic G2/MI DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
checkpoint clamp complex protein Rad1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4978578..4980303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020238.3 → NP_594809.1  checkpoint clamp complex protein Rad1 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P22193
    Conserved Domains (2) summary
    pfam02144
    Location:2 → 262
    Rad1; Repair protein Rad1/Rec1/Rad17
    cl24017
    Location:8 → 281
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
Nucleotide Protein
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