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wis2 cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542541, updated on 18-Sep-2024

Summary

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Official Symbol
wis2
Official Full Name
cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2
Primary source
PomBase:SPAC1B3.03c
Locus tag
SPOM_SPAC1B3.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cyp5
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Genomic context

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See wis2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4929854..4931163, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uracil phosphoribosyltransferase Neighboring gene protein Min8 Neighboring gene Elf1 family transcription elongation factor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase GUF1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cyclophilin sensitivity to sanglifehrin A can be correlated to the same specific tryptophan residue as cyclosporin A. Pemberton TJ, et al. FEBS Lett, 2003 Dec 4. PMID 14644438
  2. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast. Burr R, et al. J Biol Chem, 2017 Sep 29. PMID 28821619, Free PMC Article
  3. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
  4. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
  5. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. Beltrao P, et al. PLoS Biol, 2009 Jun 16. PMID 19547744, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4929854..4931163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020215.3 → NP_594787.1  cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594787.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q11004
    Conserved Domains (3) summary
    sd00006
    Location:204 → 253
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:204 → 287
    TPR_11; TPR repeat
    cl00197
    Location:6 → 165
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
Nucleotide Protein
Heading Accession and Version

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