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ncs1 calcium-binding protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542523, updated on 18-Sep-2024

Summary

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Official Symbol
ncs1
Official Full Name
calcium-binding protein
Primary source
PomBase:SPAC18B11.04
Locus tag
SPOM_SPAC18B11.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ncs1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (310157..311554, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Lcp5 Neighboring gene dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase PIGV Neighboring gene ncRNA Neighboring gene N-acetyltransferase Neighboring gene ncRNA Neighboring gene tRNA pseudouridylate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. (1)H, (15)N, and (13)C chemical shift assignments of neuronal calcium sensor-1 homolog from fission yeast. Lim S, et al. Biomol NMR Assign, 2009 Dec. PMID 19851889, Free PMC Article
  2. Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers calcium tolerance. Hamasaki-Katagiri N, et al. J Biol Chem, 2004 Mar 26. PMID 14722091
  3. Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis. Willet AH, et al. J Cell Sci, 2023 Nov 1. PMID 37815455, Free PMC Article
  4. Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast. Lim S, et al. J Biol Chem, 2011 Apr 8. PMID 21288895, Free PMC Article
  5. Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast. Hamasaki-Katagiri N, et al. J Biol Chem, 2010 Feb 12. PMID 20018864, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In Ca2+-bound Ncs1, the myristoyl group is extruded (Ca2+-myristoyl switch), exposing a prominent patch of hydrophobic residues that specifically contact phosphatidylinositol 4-kinase.
    Title: Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast.
  2. Data propose that Ncs1p promotes Ca(2+) tolerance in fission yeast, in part by cytosolic Ca(2+) buffering and perhaps by negatively regulating the Yam8p Ca(2+) channel.
    Title: Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast.
  3. complete NMR chemical shift assignments of the NCS homolog Ncs1p from fission yeast
    Title: (1)H, (15)N, and (13)C chemical shift assignments of neuronal calcium sensor-1 homolog from fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
NOT enables 1-phosphatidylinositol 4-kinase activator activity EXP
Inferred from Experiment
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of calcium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network membrane EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
calcium-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    310157..311554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018279.3 → NP_592879.1  calcium-binding protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592879.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09711
    Conserved Domains (3) summary
    COG5126
    Location:9 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:100 → 172
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:36 → 86
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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