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pap1 DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542140, updated on 18-Sep-2024

Summary

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Official Symbol
pap1
Official Full Name
DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3
Primary source
PomBase:SPAC1783.07c
Locus tag
SPOM_SPAC1783.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
caf3
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Genomic context

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See pap1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2200353..2202989, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CENP-A chaperone, CHD family Hrp1 Neighboring gene ncRNA Neighboring gene autophagy-associated ubiquitin-like modifier Atg12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1. Marte L, et al. Redox Biol, 2020 Jan. PMID 31514053, Free PMC Article
  2. Protective roles and Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses. Kang MH, et al. Mol Biol Rep, 2011 Feb. PMID 20563653
  3. Gene expressions and enzyme analyses in the Schizosaccharomyces pombe Deltapap1 transcription factor mutant exposed to Cd(2+). Takács K, et al. J Basic Microbiol, 2007 Feb. PMID 17304622
  4. Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1. Calvo IA, et al. J Cell Sci, 2013 May 15. PMID 23525001
  5. A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1. Kudo N, et al. J Biol Chem, 1999 May 21. PMID 10329722

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1.
    Title: Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1.
  2. Protection from Disulfide Stress by Inhibition of Pap1 Nuclear Export in Schizosaccharomyces pombe
    Title: Protection from Disulfide Stress by Inhibition of Pap1 Nuclear Export in Schizosaccharomyces pombe.
  3. these results suggest a model in which LatA-mediated cytoskeletal perturbations are sensed, triggering the Imp1p-dependent translocation of Pap1p to the nucleus and the induction of the caf5 gene (independently of oxidative stress).
    Title: Latrunculin A-Induced Perturbation of the Actin Cytoskeleton Mediates Pap1p-Dependent Induction of the Caf5p Efflux Pump in Schizosaccharomyces pombe.
  4. Data suggest that S. pombe 972 expressing a nonphosphorylatable Atf1 variant is more sensitive to oxidative stress because of impaired transcription of subset of stress genes whose expression is controlled by Pap1; in S. pombe 972 expressing phospho-mimicking Atf1 mutant, presence of Sty1 is completely dispensable. (Atf1 = transcription factor Atf1; Sty1 = MAP kinase Sty1; Pap1 = transcription factor Pap1)
    Title: Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.
  5. A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe has been characterized.
    Title: A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe.
  6. The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.
    Title: The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.
  7. Pap1 is an alternative electron donor of Tpx1 in the absence of reduced Trx1.
    Title: Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle.
  8. this study suggests that not just one but probably two disulphide bonds are required to promote the important conformational changes that trigger Pap1 activation and nuclear accumulation.
    Title: Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1.
  9. The ability of Pap1 to bind and activate drug tolerance promoters is independent on Prr1, whereas its affinity for the antioxidant promoters is significantly enhanced upon association with Prr1.
    Title: The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.
  10. analysis of Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses
    Title: Protective roles and Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific EXP
Inferred from Experiment
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2200353..2202989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019094.3 → NP_593662.1  DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q01663, Q9US23, Q9UU69
    Conserved Domains (2) summary
    cd14688
    Location:77 → 139
    bZIP_YAP; Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain
    pfam08601
    Location:149 → 548
    PAP1; Transcription factor PAP1
Nucleotide Protein
Heading Accession and Version

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Research Materials