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mcs4 response regulator Mcs4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541209, updated on 18-Sep-2024

Summary

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Official Symbol
mcs4
Official Full Name
response regulator Mcs4
Primary source
PomBase:SPBC887.10
Locus tag
SPOM_SPBC887.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mcs4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3557088..3559137)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA pseudouridine synthase Pus2 Neighboring gene ncRNA Neighboring gene P-type ATPase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe. Takatsume Y, et al. J Biol Chem, 2006 Apr 7. PMID 16464860
  2. Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator. Aoyama K, et al. J Bacteriol, 2000 Sep. PMID 10940030, Free PMC Article
  3. Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces pombe cell cycle control. Cottarel G. Genetics, 1997 Nov. PMID 9383051, Free PMC Article
  4. Two-component signaling to the stress MAP kinase cascade in fission yeast. Morigasaki S, et al. Methods Enzymol, 2010. PMID 20946853
  5. Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase. Nguyen AN, et al. Mol Biol Cell, 2000 Apr. PMID 10749922, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Mcs4 is required for stable heteromer formation between the Wis4 and Win1 MAPKKKs.
    Title: Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.
  2. results suggest that S. pombe has an alternative module(s) that directs the methylglyoxal signal to the SAPK pathway via Mcs4
    Title: Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables phosphorelay response regulator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Mcs4 RR-MAPKKK complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mcs4 RR-MAPKKK complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Mcs4 RR-MAPKKK complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
response regulator Mcs4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3557088..3559137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022404.3 → NP_596484.1  response regulator Mcs4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596484.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P87323, Q9UTZ6
    Conserved Domains (1) summary
    cd00156
    Location:365 → 504
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
Nucleotide Protein
Heading Accession and Version

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