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csc1 FHA domain-containing protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541013, updated on 18-Sep-2024

Summary

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Official Symbol
csc1
Official Full Name
FHA domain-containing protein
Primary source
PomBase:SPBC3H7.13
Locus tag
SPOM_SPBC3H7.13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
far10
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Genomic context

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See csc1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (1859004..1861268, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene U3 snoRNP-associated protein Esf2 Neighboring gene beige protein 1 Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase (CK1 family) Hhp1 Neighboring gene ncRNA Neighboring gene BRCT domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RAVE complex subunit Rav2 Neighboring gene actin binding methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain. Willet AH, et al. Mol Biol Cell, 2024 Aug 1. PMID 38865179, Free PMC Article
  2. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Frost A, et al. Cell, 2012 Jun 8. PMID 22682253, Free PMC Article
  3. Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast. Miki F, et al. Mol Genet Genomics, 2004 Jan. PMID 14655046
  4. Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA. Zhang K, et al. Science, 2011 Mar 25. PMID 21436456, Free PMC Article
  5. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables spindle pole body anchor activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric protein localization to old mitotic spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of septation initiation signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of septation initiation signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex EXP
Inferred from Experiment
more info
 PubMed 
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitotic spindle pole body EXP
Inferred from Experiment
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 

General protein information

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Preferred Names
FHA domain-containing protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1859004..1861268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021663.3 → NP_595762.1  FHA domain-containing protein [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74388
    Conserved Domains (2) summary
    COG1716
    Location:19 → 116
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:4 → 110
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
Nucleotide Protein
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