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pac1 double-strand-specific ribonuclease Pac1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540084, updated on 18-Sep-2024

Summary

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Official Symbol
pac1
Official Full Name
double-strand-specific ribonuclease Pac1
Primary source
PomBase:SPBC119.11c
Locus tag
SPOM_SPBC119.11C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
hcs; rnt1; snm1
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Genomic context

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See pac1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (737503..738826, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene asparagine synthetase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene golgin protein Rud3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased multiple virus resistance in transgenic soybean overexpressing the double-strand RNA-specific ribonuclease gene PAC1. Yang X, et al. Transgenic Res, 2019 Feb. PMID 30506433
  2. A mutation in a single gene of Schizosaccharomyces pombe affects the expression of several snRNAs and causes defects in RNA processing. Potashkin J, et al. EMBO J, 1990 Feb. PMID 2406130, Free PMC Article
  3. Purification and characterization of the Pac1 ribonuclease of Schizosaccharomyces pombe. Rotondo G, et al. Nucleic Acids Res, 1996 Jun 15. PMID 8710510, Free PMC Article
  4. Substrate structure requirements of the Pac1 ribonuclease from Schizosaccharmyces pombe. Rotondo G, et al. RNA, 1997 Oct. PMID 9326493, Free PMC Article
  5. Pac1p, an RNase III homolog, is required for formation of the 3' end of U2 snRNA in Schizosaccharomyces pombe. Zhou D, et al. RNA, 1999 Aug. PMID 10445882, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast.
    Title: Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast.
  2. our results showed that overexpression of PAC1 can increase multiple virus resistance in transgenic soybean, and thus provide an efficient control strategy against RNA viruses such as SMV, BCMV, WMV, and BPMV.
    Title: Increased multiple virus resistance in transgenic soybean overexpressing the double-strand RNA-specific ribonuclease gene PAC1.
  3. Pac1 and Dhp1p are essential for RNA production and transcript termination.
    Title: Pac1 endonuclease and Dhp1p 5'-->3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease III activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in U2 snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in U2 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in box C/D sno(s)RNA 5'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of RNA polymerase II transcription, exosome-dependent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
double-strand-specific ribonuclease Pac1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    737503..738826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021199.3 → NP_595292.1  double-strand-specific ribonuclease Pac1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595292.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P22192, Q4JFF8, Q670L9
    UniProtKB/TrEMBL
    Q152U6
    Conserved Domains (3) summary
    smart00358
    Location:291 → 354
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:136 → 359
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00593
    Location:141 → 282
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
Nucleotide Protein
Heading Accession and Version

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