U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

brl2 histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539307, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
brl2
Official Full Name
histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2
Primary source
PomBase:SPCC970.10c
Locus tag
SPOM_SPCC970.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rfp1
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See brl2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (489781..493167)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene wtf antidote-like meiotic drive suppressor Wtf9 Neighboring gene exocyst complex subunit Exo4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene inositol polyphosphate kinase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Tanny JC, et al. Genes Dev, 2007 Apr 1. PMID 17374714, Free PMC Article
  2. The absence of histone H2B monoubiquitination in the Arabidopsis hub1 (rdo4) mutant reveals a role for chromatin remodeling in seed dormancy. Liu Y, et al. Plant Cell, 2007 Feb. PMID 17329563, Free PMC Article
  3. New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe. Maki T, et al. PLoS Genet, 2018 May. PMID 29852001, Free PMC Article
  4. HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast. Zofall M, et al. J Biol Chem, 2007 May 11. PMID 17363370
  5. Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription. Sansó M, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32496538, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H2B C-terminal K residue ubiquitin ligase activity EXP
Inferred from Experiment
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in donor selection IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation-coupled chromatin remodeling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    489781..493167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022838.3 → NP_587845.1  histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587845.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74563
    Conserved Domains (2) summary
    smart00184
    Location:627 → 666
    RING; Ring finger
    pfam08647
    Location:433 → 525
    BRE1; BRE1 E3 ubiquitin ligase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials