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gcn3 translation initiation factor eIF2B alpha subunit Gcn3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539154, updated on 18-Sep-2024

Summary

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Official Symbol
gcn3
Official Full Name
translation initiation factor eIF2B alpha subunit Gcn3
Primary source
PomBase:SPCC11E10.07c
Locus tag
SPOM_SPCC11E10.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
tif221
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Genomic context

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See gcn3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003421.2 (1464630..1466019, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene elongator complex subunit Elp4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-amylase-like protein Neighboring gene CLRC ubiquitin ligase complex WD repeat protein Rik1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of eIF2B and insights into eIF2-eIF2B interactions. Kashiwagi K, et al. FEBS J, 2017 Mar. PMID 27627185
  2. Structural basis for eIF2B inhibition in integrated stress response. Kashiwagi K, et al. Science, 2019 May 3. PMID 31048492
  3. Crystal structure of eukaryotic translation initiation factor 2B. Kashiwagi K, et al. Nature, 2016 Mar 3. PMID 26901872
  4. Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase. Fukuda T, et al. Elife, 2021 Feb 3. PMID 33534698, Free PMC Article
  5. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, et al. J Struct Funct Genomics, 2016 Mar. PMID 27023709, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF2B alpha subunit Gcn3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1464630..1466019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023193.3 → NP_588203.1  translation initiation factor eIF2B alpha subunit Gcn3 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9USP0
    Conserved Domains (1) summary
    COG1184
    Location:12 → 341
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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