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skb15 p21-activated protein kinase inhibitor Skb15 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538757, updated on 18-Sep-2024

Summary

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Official Symbol
skb15
Official Full Name
p21-activated protein kinase inhibitor Skb15
Primary source
PomBase:SPCC16C4.08c
Locus tag
SPOM_SPCC16C4.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See skb15 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003421.2 (675369..677181, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene tRNA pseudouridine synthase Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA-binding protein Scw1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dis3L2-like 3'-5'-exoribonuclease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The kelch repeat protein, Tea1, is a potential substrate target of the p21-activated kinase, Shk1, in the fission yeast, Schizosaccharomyces pombe. Kim H, et al. J Biol Chem, 2003 Aug 8. PMID 12764130
  2. The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe. Qyang Y, et al. Mol Microbiol, 2002 Apr. PMID 11972773
  3. Genetic and molecular characterization of Skb15, a highly conserved inhibitor of the fission yeast PAK, Shk1. Kim HW, et al. Mol Cell, 2001 May. PMID 11389855
  4. The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Saveanu C, et al. Mol Cell Biol, 2007 Apr. PMID 17308036, Free PMC Article
  5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signaling NAS
Non-traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
p21-activated protein kinase inhibitor Skb15

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    675369..677181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022909.3 → NP_587918.1  p21-activated protein kinase inhibitor Skb15 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587918.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74453, Q96VR0
    Conserved Domains (3) summary
    COG2319
    Location:30 → 280
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:31 → 267
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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