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Tnfrsf11b TNF receptor superfamily member 11B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25341, updated on 27-Nov-2024

Summary

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Official Symbol
Tnfrsf11bprovided by RGD
Official Full Name
TNF receptor superfamily member 11Bprovided by RGD
Primary source
RGD:619802
See related
EnsemblRapid:ENSRNOG00000008336 AllianceGenome:RGD:619802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Opg
Summary
Predicted to enable heparan sulfate binding activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; and response to estrogen. Located in extracellular space. Biomarker of congestive heart failure; myocarditis; and periapical periodontitis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 89.4), Uterus (RPKM 58.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfrsf11b in Genome Data Viewer
Location:
7q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (87456318..87484324, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (85566520..85594526, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (93798580..93826586, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 7, pseudogene 2 Neighboring gene uncharacterized LOC120093858 Neighboring gene collectin subfamily member 10 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 72

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength. Ominsky MS, et al. J Bone Miner Res, 2009 Jul. PMID 19257823
  2. [Effect of estrogen on osteoprotegerin, osteoclast differentiation factor and macrophage colony stimulating factor mRNA expressions in ovariectomized rat bone tissue]. Wang Q, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2006 Apr. PMID 16624776
  3. [Effects of soybean isoflavones on expression levels of osteoprotegerin and osteoprotegerin ligand mRNAs in bone tissues of ovariectomized rats]. Wang Q, et al. Zhong Xi Yi Jie He Xue Bao, 2006 May. PMID 16696921
  4. [Effects of kangfengshi granules on expressions of osteoprotegerin, RANKL and M-CSF in bone tissues of rats with collagen-induced arthritis]. Liu YH, et al. Zhong Xi Yi Jie He Xue Bao, 2006 May. PMID 16696922
  5. Combined effect of fluoride and arsenate on gene expression of osteoclast differentiation factor and osteoprotegerin. Jia L, et al. Biomed Environ Sci, 2006 Oct. PMID 17190191

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
    Title: Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
  2. Mechanical force regulates root resorption in rats through RANKL and OPG.
    Title: Mechanical force regulates root resorption in rats through RANKL and OPG.
  3. The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
    Title: The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
  4. The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis.
    Title: The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis.
  5. [Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats].
    Title: [Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats].
  6. Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation.
    Title: Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation.
  7. Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.
    Title: Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.
  8. Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes.
    Title: Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes.
  9. Substance P participates in periodontitis by upregulating HIF-1alpha and RANKL/OPG ratio.
    Title: Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio.
  10. S-amlodipine inhibits inflammation and protects against endothelial dysfunction, likely via regulating the RANK/RANKL/OPG pathway, which appears to be downstream of miR-155.
    Title: S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93568

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of bone resorption IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of odontogenesis of dentin-containing tooth IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to magnesium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
Osteoprotegerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012870.2 → NP_037002.1  tumor necrosis factor receptor superfamily member 11B precursor

    See identical proteins and their annotated locations for NP_037002.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081830
    UniProtKB/Swiss-Prot
    O08727
    UniProtKB/TrEMBL
    A0A8I6A1T0, A6HRF7
    Related
    ENSRNOP00000011344.3, ENSRNOT00000011344.7
    Conserved Domains (4) summary
    cd00185
    Location:145 → 186
    TNFRSF; CRD2 [structural motif]
    cd10581
    Location:7 → 151
    TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)
    pfam00531
    Location:288 → 365
    Death; Death domain
    cl22855
    Location:124 → 187
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    87456318..87484324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08727.1 GenPept UniProtKB/Swiss-Prot:O08727

Gene LinkOut

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