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Dnah12 dynein, axonemal, heavy chain 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252959, updated on 9-Dec-2024

Summary

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Official Symbol
Dnah12provided by RGD
Official Full Name
dynein, axonemal, heavy chain 12provided by RGD
Primary source
RGD:619990
See related
EnsemblRapid:ENSRNOG00000059865 AllianceGenome:RGD:619990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bm259
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to be located in axoneme and microtubule. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Orthologous to human DNAH12 (dynein axonemal heavy chain 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 131.8), Lung (RPKM 86.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnah12 in Genome Data Viewer
Location:
16p16
Exon count:
78
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1932776..2099391)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1936354..2092663)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2377218..2534130)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ARF GTPase 4 Neighboring gene phosphodiesterase 12 Neighboring gene protein phosphatase 1, regulatory subunit 26, pseudogene 1 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene host cell factor C1 regulator 1-like Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats. Kirsch T, et al. Brain Res, 2001 Aug 10. PMID 11489260
  2. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
  3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 12
Names
axonemal dynein heavy chain 12-like protein
dynein heavy chain 12, axonemal
dynein, axonemal, heavy polypeptide 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419553.1 → NP_001406482.1  dynein axonemal heavy chain 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A0G2K7D4
    Related
    ENSRNOP00000074159.2, ENSRNOT00000079215.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    1932776..2099391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275064.1 → XP_063131134.1  dynein axonemal heavy chain 12 isoform X1

    UniProtKB/TrEMBL
    A6KMJ8

  2. XM_063275066.1 → XP_063131136.1  dynein axonemal heavy chain 12 isoform X3

    UniProtKB/TrEMBL
    A6KMJ8

  3. XM_063275065.1 → XP_063131135.1  dynein axonemal heavy chain 12 isoform X2

    UniProtKB/TrEMBL
    A6KMJ8

  4. XM_063275067.1 → XP_063131137.1  dynein axonemal heavy chain 12 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K7D4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923J6.2 GenPept UniProtKB/Swiss-Prot:Q923J6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials