Dgat2 diacylglycerol O-acyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dgat2provided by RGD
Official Full Name: diacylglycerol O-acyltransferase 2provided by RGD
Primary source: RGD:620329
See related: EnsemblRapid:ENSRNOG00000016573 AllianceGenome:RGD:620329
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ARAT
Summary: Enables diacylglycerol O-acyltransferase activity. Involved in several processes, including diacylglycerol metabolic process; positive regulation of gluconeogenesis; and regulation of lipid metabolic process. Predicted to be located in several cellular components, including lipid droplet; mitochondrion; and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Used to study steatotic liver disease. Biomarker of chronic kidney disease and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1324.8), Thymus (RPKM 669.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (162866237..162896655, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153454078..153484432, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164113459..164143818, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interaction of DGAT2 and MGAT2 serves to channel lipid substrates efficiently for triacylglycerol biosynthesis.
Title: Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis.
The effect of osthole on protein expression of PPARalpha/gamma and related target molecules such as CYP7A and DGAT protein expression in the liver of hyperlipidemic fatty liver rats.
Title: Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.
DGAT2, but not DGAT1, has a role in diet-induced hepatic steatosis and insulin resistance
Title: Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
ontogeny of the two functional diacylglycerol acyltransferase (DGAT) activities (overt and latent) during postnatal development in rat liver
Title: Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139205 (e-PCR)
- UniSTS:221291

G42985 (e-PCR)
- UniSTS:94858

RH134485 (e-PCR)
- UniSTS:217765

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-acylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 2-acylglycerol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables retinol O-fatty-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oleic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oleic acid	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in diacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fat pad development	IEA Inferred from Electronic Annotation more info
involved_in fat pad development	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty-acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty-acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of plasma lipoprotein particle levels	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diacylglycerol O-acyltransferase 2

Names: acyl-CoA retinol O-fatty-acyltransferase; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase

NP_001012345.1

EC 2.3.1.20

EC 2.3.1.76

XP_006229795.1

EC 2.3.1.20

EC 2.3.1.76

XP_008757911.1

EC 2.3.1.20

EC 2.3.1.76

XP_038957461.1

EC 2.3.1.20

EC 2.3.1.76

XP_038957462.1

EC 2.3.1.20

EC 2.3.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012345.1 → NP_001012345.1 diacylglycerol O-acyltransferase 2

See identical proteins and their annotated locations for NP_001012345.1

Status: PROVISIONAL

Source sequence(s)

BC089846

UniProtKB/Swiss-Prot

Q5FVP8, Q8K4Y4

UniProtKB/TrEMBL

A0A0G2JUZ8

Related

ENSRNOP00000022557.6, ENSRNOT00000022557.8

Conserved Domains (1) summary

pfam03982
Location:92 → 388

DAGAT; Diacylglycerol acyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

162866237..162896655 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101533.2 → XP_038957461.1 diacylglycerol O-acyltransferase 2 isoform X2

UniProtKB/TrEMBL

A0A0G2JUZ8, A0A8I6A5T7

Conserved Domains (1) summary

pfam03982
Location:49 → 345

DAGAT; Diacylglycerol acyltransferase
XM_008759689.4 → XP_008757911.1 diacylglycerol O-acyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A5T7

Conserved Domains (1) summary

pfam03982
Location:68 → 364

DAGAT; Diacylglycerol acyltransferase
XM_006229733.5 → XP_006229795.1 diacylglycerol O-acyltransferase 2 isoform X3

UniProtKB/TrEMBL

A0A0G2JUZ8, A0A8I6A5T7

Conserved Domains (1) summary

pfam03982
Location:28 → 324

DAGAT; Diacylglycerol acyltransferase
XM_039101534.2 → XP_038957462.1 diacylglycerol O-acyltransferase 2 isoform X4

Conserved Domains (1) summary

cl17185
Location:1 → 223

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis